1 Alison Dilaurentis (Pretty Little Liars)
Amazing 😉 cheeky person
Just when we thought it couldn’t get any worse than mean girl Regina George, Alison DiLaurentis flew onto the scene and rocked our worlds! Underneath her golden locks are mental files full of secrets. Behind that pretty smile is her weapon of a tongue, ready to manipulate anyone who crosses her path. There’s much to hate about this queen bee, yet there’s no denying how captivating, clever and gorgeous she is.
2 Blair Waldorf (Gossip Girl)
Blair Cornelia Waldorf is the main character of Gossip Girl, introduced in the original series of novels and also appearing in the television and manga adaptations.
She should be higher than Serena!
3 Regina George (Mean Girls)
Regina Liliana George is the lead antagonist of the movie Mean Girls . She is portrayed by Rachel McAdams . ...read more.
"Get In Loser, We're Going Shopping! "
Lol, no surprise here.
4 Serena Van Der Woodsen (Gossip Girl)
Serena Celia van der Woodsen is a main character in the Gossip Girl novel series and its TV adaptation, in which she is portrayed by Blake Lively.
Serena wasn't really the alpha female, blair was - pjo
5 Massie Block (The Clique)
6 Cherilyn Horowitz (Clueless)
7 Sharpay Evans (High School Musical Franchise)
8 Paige Michalchuk (Degrassi the Next Generation)
9 Kathryn Merteuil (Cruel Intentions)
10 Kate Sanders (Lizzie McGuire)
11 Hanna Marin (Pretty Little Liars)
Hanna Olivia Marin is a fictional character created by Sara Shepard for the Pretty Little Liars book series, and later developed for the Freeform television series adaptation by I.
12 Chanel Oberlin (Scream Queens)
13 Dalia Royce (Suburgatory)
She needs a spin off show
14 Maddie Van Pelt (Every Witch Way)
15 Bonnie Rockwaller (Kim Possible)
16 Hit Girl/Mindy Macready (Kick-Ass)
She is a full-alpha preteen in the first movie, but in the second one, she is a socially unsure high schooler at first.
The resident "mean girls" at school score a lot of early points against her, but in the end she makes them regret it big time.
17 Hilly Holbrook (The Help)
18 Claire Brewster (Beetlejuice)
19 Mandy (Totally Spies!)
20 Mindy (The Grim Adventures of Billy & Mandy)
21 Princess Morbucks (The Powerpuff Girls)
22 Maris (Unfabulous)
23 Tricia Holmes (6teen)
24 Isis (Bring It On)
25 Ashley Armbruster (Recess)
26 Heather Chandler (Heathers)
27 Santana Lopez (Glee)
28 Wilhelmina Slater (Ugly Betty)
29 Betty Rizzo (Grease)
30 Jenna Maroney (30 Rock)
31 Lucille Bluth (Arrested Development)
32 Karen Walker (Will & Grace)
33 Nina Harper (Braceface)
34 Rachel Witchburn (Sydney White)
35 Lexi Reed (A.N.T. Farm)
Lexi Reed (Stefanie Scott) is Chyna's biggest rival at Webster High. Chyna is seen to be the leader of the ANTs, but Lexi still considers herself the Queen Bee. However, if necessary she will ally with Chyna and her friends. Eventually, she becomes student body president. Her best friend and sidekick ...read more.
36 Shelby Cummings (A Cinderella Story)
37 Amber Whitmore (Casper)
38 Kirsten (Never Been Kissed)
39 Courtney (Jawbreaker)
40 Taylor Vaughn (She's All That)
41 Jessica Spencer
42 Madison (The Duff)
43 Marianne Bryant (Easy A)
44 Amber Von Tussle (Hairspray)
45 Mertle (Lilo & Stitch)
46 Jenna (Max Keeble's Big Move)
47 Priscilla (Not Another Teen Movie)
48 Chelsea (Princess Protection Program)
49 Stacy (Radio Rebel)
50 Christie Masters (Romy and Michele's High School Reunion)