Top Ten Anime Franchises with the Most Powerful Beings

These are some of the anime series with the most powerful beings ever in fiction. Just to clarify, anime with only one very powerful character or that said character isn't aware of his/her powers, thus, unable to use his/her power to the full extent will be below another with slightly weaker characters but in a larger number. To put it simply the anime higher on the list has to be capable of winning against the lower ones in a fight.
E.g.: Haruhi Suzumiya is a lot more powerful than Goku, but she's much slower, and she is unaware of her powers, so she wouldn't be able to command him out of existence faster than his being able to blast her into oblivion. Same goes for the case of Eucliwood Hellscythe. Speed has to be taken into account.
The Top Ten
1 Tenchi Muyo Franchise Tenchi Muyo! is a Japanese anime and manga franchise created by Masaki Kajishima. The series debuted in 1992 and explores the adventures of Tenchi Masaki, a young man who discovers his connection to alien royalty. Mixing elements of science fiction, fantasy, and harem genres, the franchise has spawned numerous sequels, spin-offs, and adaptations across various media. Tenchi Muyo! has garnered a large international following and is influential within the anime community.

Kami Tenchi is omnipotent, and the Choushin are nigh omnipotent as well.

2 Demonbane Franchise

This verse has Azathoth, an omnipotent being like Kami Tenchi, and many characters even more powerful than the Choushin! Too overpowered.

3 Umineko no Naku Koro ni Franchise
4 Demon King Daimao Franchise
5 Saint Seiya Franchise
6 Slayers Franchise
7 Medaka Box Franchise
8 Ah! My Goddess Franchise
9 Puella Magi Madoka Magica Franchise Puella Magi Madoka Magica is a 2011 Japanese anime television series produced by Shaft and Aniplex, directed by Akiyuki Shinbo, written by Gen Urobuchi, music by Yuki Kajiura, opening sang by ClariS, ending by Kalafina (sometimes by the seiyuus) and original characters by Ume Aoki.
10 Sailor Moon Franchise Sailor Moon is a Japanese shōjo manga series by Naoko Takeuchi. It was originally serialized in Nakayoshi from 1991 to 1997; the 52 individual chapters were published in 18 tankōbon volumes. ...read more.
The Contenders
11 Gurren Lagann Franchise Gurren Lagann, known in Japan as Tengen Toppa Gurren Lagann, is an anime series animated by Gainax and co-produced by Aniplex and Konami. It was also directed by Hiroyuki Imaishi and written by veteran playwright Kazuki Nakashima.
12 Dragon Ball Super Franchise Dragon Ball Super is a Japanese anime television series produced by Toei Animation that began airing on July 5, 2015. It is a sequel show to the Dragon Ball manga and the first Dragon Ball television series featuring a new storyline in 18 years.
13 Serial Experiments Lain Franchise Serial Experiments Lain is an anime series that was directed by Ryutaro Nakamura. The characters were designed by Yoshitoshi ABe, the script was penned by Chiaki J. Konaka, and the production was handled by Yasuyuki Ueda for Triangle Staff. The series aired on TV Tokyo from July to September in 1998. It explores various themes such as reality, identity, and communication, using elements of philosophy,... read more
14 Dragon Ball Z Franchise
15 Doraemon Franchise
16 The Melancholy of Haruhi Suzumiya Franchise Haruhi Suzumiya (Japanese: 涼宮ハルヒ, Hepburn: Suzumiya Haruhi) is a Japanese light novel series written by Nagaru Tanigawa and illustrated by Noizi Ito. It was first published in 2003 by Kadokawa Shoten in Japan with the novel The Melancholy of Haruhi Suzumiya, and has since been followed by 11 additional novel volumes, an anime television series adaptation produced by Kyoto Animation, four manga series, an animated film, two original net animation series and several video games. ...read more.

This is added here thanks to Sasaki, rather than Haruhi. She has the same powers as Haruhi, except that she is aware of her powers.

17 Kore Wa Zombie Desu Ka? Franchise
18 Pokémon Franchise Pokémon, abbreviated from the Japanese title of Pocket Monsters and currently advertised in English as Pokémon: The Series, is a Japanese anime television series, which has been adapted for the international television markets. It was first broadcast in Japan on April 1, 1997, in the United States ...read more.
19 Yu-Gi-Oh! Franchise Yu-Gi-Oh! was aired from 2000 to 2004 in Japan, and 2001 to 2006 in the US. It continues where the Toei Anime Left off. When 10th grader Yugi Muto solves the Millenium Puzzle, Yami Yugi emerges, taking control of him to help his friends. In Duel Monsters, they mostly played children's card games because ...read more.
20 Digimon Franchise “Digimon” is a term commonly used to describe a variety of Japanese anime series based on the Bandai virtual pet brand “Digimon” (Dejimon). As of 2017, there are 7 series: “Digimon Adventure” (1999), “Digimon 02” (a.k.a. “Digimon Adventure 02”) (2000), “Digimon Tamers” (2001), ...read more.
21 Shaman King Franchise
22 Jojo's Bizarre Adventure Franchise
23 Fairy Tail Franchise
24 Magi : The Labyrinth of Magic Franchise
25 Bobobo-bo Bo-bobo Bobobo-bo Bo-bobo is a Japanese anime and manga series created by Yoshio Sawai. It originally aired from 2003 to 2005 and is known for its surreal, nonsensical humor. The series revolves around the protagonist, Bobobo-bo Bo-bobo, as he fights against an evil empire that wants to shave the world's population bald. The show has been praised for its unique humor, but also noted for its extremely quirky and bizarre storyline.

Basically, weirdness powers and randomness combine to make parodies. Also, Try going super saiyan without being a saiyan at all. Try to stand up to Hajike or wiggin out at times. That is my answer

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