Top 10 Best Anime with a Female Protagonist

The Top Ten
1 Ghost in the Shell Debuting in 1995 as an anime film, Ghost in the Shell was based on a manga by Masamune Shirow. The franchise has since expanded into multiple series and films. It explores themes of identity, artificial intelligence, and existentialism through its protagonist, Major Motoko Kusanagi, a cyborg federal agent in a future Japan. The franchise has had a significant impact on cyberpunk culture and media.
2 Moribito: Guardian of the Spirit
3 Psycho-Pass Psycho-Pass is an anime television series that was produced by Production I.G, directed by Naoyoshi Shiotani & Katsuyuki Motohiro and written by Gen Urobuchi.
4 Sailor Moon Sailor Moon is a Japanese shōjo manga series by Naoko Takeuchi. It was originally serialized in Nakayoshi from 1991 to 1997; the 52 individual chapters were published in 18 tankōbon volumes.

Usagi Tsukino is an average student and crybaby klutz who constantly scores low on her tests. Unexpectedly, her humdrum life is turned upside down when she saves a cat with a crescent moon on its head... read more
5 Puella Magi Madoka Magica Puella Magi Madoka Magica is a 2011 Japanese anime television series produced by Shaft and Aniplex, directed by Akiyuki Shinbo, written by Gen Urobuchi, music by Yuki Kajiura, opening sang by ClariS, ending by Kalafina (sometimes by the seiyuus) and original characters by Ume Aoki.
6 Yona of the Dawn Yona of the Dawn is a Japanese manga series by Mizuho Kusanagi, serialized in Hakusensha's shōjo manga magazine Hana to Yume from August 2009. It has been collected in twenty tankōbon volumes. A 24-episode anime television series adaptation produced by Pierrot aired between October 2014 and March 2015.
7 Tamayura
8 Azumanga Daioh Azumanga Daioh (Japanese: あずまんが大王, Hepburn: Azumanga Daiō) is a Japanese yonkoma comedy manga series written and illustrated by Kiyohiko Azuma. It was serialized from February 1999 to May 2002 in the monthly magazine Dengeki Daioh by MediaWorks; three additional chapters were published in Shogakukan's Monthly Shōnen Sunday in May 2009 to celebrate the manga's tenth anniversary. The... read more
9 Magical Girl Lyrical Nanoha Magical Girl Lyrical Nanoha is a Japanese anime television series directed by Akiyuki Shinbo, with screenplay written by Masaki Tsuzuki, and produced by Seven Arcs.
10 Non Non Biyori
The Contenders
11 Blood-C
12 HeartCatch PreCure Heartcatch Precure is a Japanese anime series and the seventh series of the Pretty Cure anime franchise by Izumi Todo that premiered on February 7, 2010, replacing Fresh Pretty Cure! on its initial timeslot. The series theme is flowers, which leads to their true definitions of Hanakotoba as of the season's true scheme.
13 Cardcaptor Sakura Cardcaptor Sakura, abbreviated as CCS and also known as Cardcaptors, is a Japanese shōjo manga series written and illustrated by the manga group Clamp.
14 Yuru Yuri
15 K-On! K-ON! (けいおん!, literally 'Light Music') is a Japanese slice of life and comedy four-panel comic strip manga written and illustrated by Kakifly. It was serialized from 2007 to 2012, and there are six volumes to the manga in total. Kyoto Animation produced the anime adaptation, which aired over 2009 and 2010, over two seasons of 12 and 24 episodes respectively, with many extras, bonus shorts,... read more
16 Ergo proxy Ergo Proxy is a science fiction suspense anime television series, produced by Manglobe, directed by Shukō Murase and written by Dai Satō.
17 ViViD Strike!
18 Mai-Hime
19 Shakugan no Shana Shakugan no Shana is an anime series including three television series, original video animation episodes, and bonus shorts.
20 Save Me Lollipop!
21 Claymore Claymore is a dark fantasy manga series written and illustrated by Norihiro Yagi. The series initially premiered in the now defunct Monthly Shōnen Jump in the May 2001 issue, but was moved to one of their sister magazines as the content was deemed too adult for Shōnen Jump’s target demographic.
22 Medaka Box
23 WataMote
24 Black Lagoon Black Lagoon (stylized in all caps) is a Japanese manga series written and illustrated by Rei Hiroe. It has been published in Shogakukan's seinen manga magazine Monthly Sunday Gene-X since April 2002, with its chapters collected in twelve tankōbon volumes as of August 2021. In North America, the manga is licensed for English release by Viz Media... read more
25 Jūsō Kikō Dancouga Nova
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