Just my favorites, many worthy candidates remain...
1 Dr. Moriarty (Sherlock Holmes)
I liked reading this book and the antagonist was pretty good - Phillip873
2 Satan (Paradise Lost)
If anything, Milton's work is an affirmation of your beliefs - Ned964
He's actually real...
There is nothing in the list heading that suggests an entry qualify as real or fictional... - Ned964
3 Count Dracula (Bram Stoker's Dracula)
4 Iago (Othello)
5 Hannibal Lecter (Red Dragon)
6 The Wicked Witch of the West (The Wonderful Wizard of Oz)
Dreadful woman; if only for that ear-splitting laugh alone! Awful. - Britgirl
7 Sauron (The Lord of the Rings)
Sauron is the title character and main antagonist of J. R. R. Tolkien's The Lord of the Rings. Originally a servant of the first Dark Lord, Morgoth. Morgoth was later defeated and Sauron fled. He later came back to Middle Earth and took over as the new Dark Lord by using a Ring of Power. He was later ...read more.
8 Mr. Dark (Something Wicked This Way Comes)
9 Lord Voldemort (Harry Potter)
Lord Voldemort is a fictional character and the central main antagonist in J. K. Rowling's series of Harry Potter novels. Voldemort first appeared in Harry Potter and the Philosopher's Stone, which was released in 1997.
10 Patrick Bates (American Psycho)
11 Cruella de Vil (One Hundred and One Dalmatians)
Cruella de Vil is a fictional character who appeared in Dodie Smith's 1956 novel The Hundred and One Dalmatians, Disney's animated film adaptations 101 Dalmatians and 101 Dalmatians II: Patch's London Adventure, and Disney's live-action film adaptations 101 Dalmatians and 102 Dalmatians as the main ...read more.
I just don't like her - Ned964
12 Gollum (The Lord of the Rings)
Gollum is a fictional character from J. R. R. Tolkien's legendarium. He was introduced in the 1937 children's fantasy novel The Hobbit, and became an important supporting character in its sequel, The Lord of the Rings.
One of the best written villains ever. His character, history and development is so great.
13 Napoleon Bonaparte (War and Peace)
14 Captain Hook (Peter Pan)
Captain James Hook is a fictional character, the antagonist of J. M. Barrie's play Peter Pan; or, the Boy Who Wouldn't Grow Up and its various adaptations, in which he is Peter Pan's archenemy.
15 Edgar Linton (Wuthering Heights)
16 Bill Sikes (Oliver Twist)
Oh...wow! Yes. Absolutely Bill Sykes should be here! Despicable creature. He has all the charm of an iron lung. - Britgirl
17 Randall Flagg (The Stand)
18 The Crimson King (The Dark Tower)
19 Mr. Wickham (Pride & Prejudice)
20 Fernand Mondego (The Count of Monte Cristo)
21 General Zaroff (The Most Dangerous Game)
22 Mr. Bumble (Oliver Twist)