Top Ten Antagonists in Literature

Just my favorites, many worthy candidates remain...
The Top Ten
1 Dr. Moriarty (Sherlock Holmes)

I liked reading this book and the antagonist was pretty good

2 Count Dracula (Bram Stoker's Dracula)
3 Satan (Paradise Lost)

He's actually real...

4 Iago (Othello)
5 Hannibal Lecter (Red Dragon) Dr. Hannibal Lecter is a character in a series of suspense novels by Thomas Harris. Lecter was introduced in the 1981 thriller novel Red Dragon as a forensic psychiatrist and cannibalistic serial killer.
6 Lord Voldemort (Harry Potter) Lord Voldemort is a fictional character and the central main antagonist in J. K. Rowling's series of Harry Potter novels. Voldemort first appeared in Harry Potter and the Philosopher's Stone, which was released in 1997.
7 The Wicked Witch of the West (The Wonderful Wizard of Oz)

Dreadful woman; if only for that ear-splitting laugh alone! Awful.

8 Bill Sikes (Oliver Twist)

Oh...wow! Yes. Absolutely Bill Sykes should be here! Despicable creature. He has all the charm of an iron lung.

Even Satan hates this guy!
He has the most punch able face ever!

He's to literature what The Joker is to comics and films!

He deserved worse than just being shot and hanged!

9 Sauron (The Lord of the Rings) Sauron is the title character and main antagonist of J. R. R. Tolkien's The Lord of the Rings. Originally a servant of the first Dark Lord, Morgoth. Morgoth was later defeated and Sauron fled. He later came back to Middle Earth and took over as the new Dark Lord by using a Ring of Power. He was later trapped by having his Ring of Power cut off his finger. He lived in a shapeless form. Sauron was remanifested as a necromancer and after being banished by a group of elves and wizards, Sauron took over the mind of Saruman. They went out and searched for the Ring. Sauron was finally defeated in the War of the Ring.
10 Gollum (The Lord of the Rings) Gollum is a fictional character from J. R. R. Tolkien's legendarium. He was introduced in the 1937 children's fantasy novel The Hobbit, and became an important supporting character in its sequel, The Lord of the Rings. In Peter Jackson's Lord of the Rings and Hobbit trilogies, he is portrayed via motion capture by Andy Serkis.

One of the best written villains ever. His character, history and development is so great.

The Contenders
11 Fernand Mondego (The Count of Monte Cristo)
12 Napoleon Bonaparte (War and Peace)

Technically yes

13 Mr. Dark (Something Wicked This Way Comes)
14 Captain Hook (Peter Pan) Captain James Hook is a fictional character, the antagonist of J. M. Barrie's play Peter Pan; or, the Boy Who Wouldn't Grow Up and its various adaptations, in which he is Peter Pan's archenemy.
15 Edgar Linton (Wuthering Heights)
16 Patrick Bates (American Psycho)
17 Cruella de Vil (One Hundred and One Dalmatians) Cruella de Vil is a fictional character who appeared in Dodie Smith's 1956 novel The Hundred and One Dalmatians, Disney's animated film adaptations 101 Dalmatians and 101 Dalmatians II: Patch's London Adventure, and Disney's live-action film adaptations 101 Dalmatians and 102 Dalmatians as the main antagonist.
18 Randall Flagg (The Stand)
19 Mr. Jaggers (Great Expectations)
20 The Crimson King (The Dark Tower)
21 Mr. Wickham (Pride & Prejudice)
22 General Zaroff (The Most Dangerous Game)
23 Mr. Bumble (Oliver Twist)
24 Fagin (Oliver Twist)
25 Mrs. Sowerberry (Oliver Twist)
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