Just my favorites, many worthy candidates remain...
1 Dr. Moriarty (Sherlock Holmes)
I liked reading this book and the antagonist was pretty good - Phillip873
2 Count Dracula (Bram Stoker's Dracula)
3 Satan (Paradise Lost)
He's actually real...
4 Iago (Othello)
5 Hannibal Lecter (Red Dragon)
Dr. Hannibal Lecter is a character in a series of suspense novels by Thomas Harris. Lecter was introduced in the 1981 thriller novel Red Dragon as a forensic psychiatrist and cannibalistic serial killer.
6 Lord Voldemort (Harry Potter)
Lord Voldemort is a fictional character and the central main antagonist in J. K. Rowling's series of Harry Potter novels. Voldemort first appeared in Harry Potter and the Philosopher's Stone, which was released in 1997.
7 The Wicked Witch of the West (The Wonderful Wizard of Oz)
Dreadful woman; if only for that ear-splitting laugh alone! Awful. - Britgirl
8 Sauron (The Lord of the Rings)
Sauron is the title character and main antagonist of J. R. R. Tolkien's The Lord of the Rings. Originally a servant of the first Dark Lord, Morgoth. Morgoth was later defeated and Sauron fled. He later came back to Middle Earth and took over as the new Dark Lord by using a Ring of Power. He was later ...read more.
9 Gollum (The Lord of the Rings)
Gollum is a fictional character from J. R. R. Tolkien's legendarium. He was introduced in the 1937 children's fantasy novel The Hobbit, and became an important supporting character in its sequel, The Lord of the Rings.
One of the best written villains ever. His character, history and development is so great.
10 Bill Sikes (Oliver Twist)
Oh...wow! Yes. Absolutely Bill Sykes should be here! Despicable creature. He has all the charm of an iron lung. - Britgirl
11 Fernand Mondego (The Count of Monte Cristo)
12 Napoleon Bonaparte (War and Peace)
13 Mr. Dark (Something Wicked This Way Comes)
14 Captain Hook (Peter Pan)
Captain James Hook is a fictional character, the antagonist of J. M. Barrie's play Peter Pan; or, the Boy Who Wouldn't Grow Up and its various adaptations, in which he is Peter Pan's archenemy.
15 Edgar Linton (Wuthering Heights)
16 Patrick Bates (American Psycho)
17 Cruella de Vil (One Hundred and One Dalmatians)
Cruella de Vil is a fictional character who appeared in Dodie Smith's 1956 novel The Hundred and One Dalmatians, Disney's animated film adaptations 101 Dalmatians and 101 Dalmatians II: Patch's London Adventure, and Disney's live-action film adaptations 101 Dalmatians and 102 Dalmatians as the main ...read more.
18 Randall Flagg (The Stand)
19 The Crimson King (The Dark Tower)
20 Mr. Wickham (Pride & Prejudice)
21 General Zaroff (The Most Dangerous Game)
22 Mr. Bumble (Oliver Twist)