1 Shao Kahn - Mortal Kombat
Shao Kahn is a boss, announcer, and recurring playable character from the Mortal Kombat fighting game series. Introduced in Mortal Kombat II in 1993, he is the primary antagonist of the video game series and extended franchise.
2 Id - Xenogears
3 Ganondorf - Legend of Zelda
Ganon (Referred to as Ganondorf in human form) is a fictional character and the central antagonist of Nintendo's Legend of Zelda series. He is a power-hungry Gerudo who possesses the Triforce of Power and aims to conquer Hyrule with the remaining Triforce parts.
4 Clockwerk - Sly Cooper and the Thievius Raccoonus
5 Ridley - Metroid
6 Genocide Sans - Undertale
7 Handsome Jack - Borderlands 2
The main antagonist of the video game Borderlands 2. He is also included in the games: Borderlands: the Pre-Sequel, and Stories from the Borderlands.
8 Metal Face (Mumkhar) - Xenoblade Chronicles
9 Kefka - Final Fantasy VI
10 Bowser - Super Mario Bros.
11 Yuki Terumi - Blazblue
12 Vaas - Far Cry 3
13 GLaDOS - Portal
14 Hades - Kid Icarus: Uprising
15 Lavos - Chrono Trigger
16 Mephiles - Sonic 2006
17 M. Bison - Street Fighter
M. Bison, also known as Dictator, is a video game character created by Capcom. First introduced in Street Fighter II: The World Warrior, he is a recurring character and villain in the Street Fighter series of fighting games, acting as the primary antagonist of the series.
18 Zanza - Xenoblade Chronicles
19 Chara - Undertale
20 Dr. Andonuts - Radiation's Earthbound Halloween Hack
What is this? A demonized fan-made version of the real Dr. Andonuts from Earthbound? He wasn't a villain in any of the official Earthbound games the last time I checked. (although he created the Ultimate Chimera and affiliated with the Pigmask Army against his will in Mother 3)
21 Chairman Drek - Ratchet & Clank
22 Sephiroth - Final Fantasy VII
23 Shodan - System Shock
24 Wesker - Resident Evil
25 Shadow - Sonic The Hedgehog
26 Ballos - Cave Story
27 The Doctor - Cave Story
28 Gaster - Undertale
29 Undyne - Undertale
30 Majora - Majora's Mask
31 Fawful - Mario & Luigi
Fawful, known in Japan as Gerakobits, is a fictional character appearing in the Mario & Luigi series of role-playing video games developed by AlphaDream.
32 Spy - Team Fortress 2
33 Scorpion - Mortal Kombat
Scorpion is a recurring player character and occasional boss character from the Mortal Kombat fighting game franchise created by Ed Boon and John Tobias.
34 Gary Smith - Bully
35 Vergil - Devil May Cry
36 Elder Princess Shroob - Mario & Luigi: Partners in Time
37 Flowey (Asriel) - Undertale
38 Liquid Snake - Metal Gear Solid
39 Blood Falcon - F-Zero
40 Black Shadow - F-Zero
41 Deathborn - F-Zero
42 Metal Sonic - Sonic CD
Metal Sonic is one of Eggman’s fastest and most powerful creations. Programed to be better than Sonic in any aspect possible, he can shoot electro balls, shoot electricity downward, do a boost, and make himself invincible. He fight’s Sonic each time he gets stronger, and when he gains enough power, ...read more.
43 Wario - Super Mario Bros.
44 Dracula - Castlevania
45 Mike Tyson - Punch-Out!
46 Death - Castlevania
47 Sophia Lamb - Bioshock 2
48 Big Daddy - Bioshock
49 The Great Mighty Poo - Conker's Bad Fur Day
The Great Mighty Poo is a fictional character appearing in the 2001 video game Conker's Bad Fur Day. He is a giant, opera-singing pile of feces that appears as a boss in the sloprano chapter.
50 Master Core - Super Smash Bros.