1 Shao Kahn - Mortal Kombat
Shao Kahn is a boss, announcer, and recurring playable character from the Mortal Kombat fighting game series. Introduced in Mortal Kombat II in 1993, he is the primary antagonist of the video game series and extended franchise.
2 Id - Xenogears
3 Ridley - Metroid
Ridley is a villain from the Metroid series and a character from the Super Smash Bros. series. He's Samus Aran's archenemy and has been fighting her since day one with the first Metroid game in 1986. When Samus was three years old, Ridley murdered her parents in front of her. He is a member of the Space ...read more.
4 Ganondorf - Legend of Zelda
Ganon (Referred to as Ganondorf in human form) is a fictional character and the central antagonist of Nintendo's Legend of Zelda series. He is a power-hungry Gerudo who possesses the Triforce of Power and aims to conquer Hyrule with the remaining Triforce parts.
5 Clockwerk - Sly Cooper and the Thievius Raccoonus
6 Gill - Street Fighter
7 Mature - The King of Fighters
8 Genocide Sans - Undertale
9 Sindel - Mortal Kombat
10 Smoke - Mortal Kombat
11 Handsome Jack - Borderlands 2
Handsome Jack is the main antagonist of both Borderlands 2 and Tales from the Borderlands and the deuteragonist of Borderlands: The Pre-Sequel.
12 Wesker - Resident Evil
13 Metal Face (Mumkhar) - Xenoblade Chronicles
14 Kefka - Final Fantasy VI
15 Dr. Nefarious - Ratchet & Clank
16 Count Veger - Jak & Daxter
17 Vaas - Far Cry 3
18 Deathborn - F-Zero
19 Yuki Terumi - Blazblue
20 Undyne - Undertale
21 Jade - Mortal Kombat
Jade is a fictional character from the Mortal Kombat fighting game series by Midway Games. Debuting in 1993's Mortal Kombat II as an unplayable secret character who was a green palette swap of Kitana, Jade made her first playable appearance in Ultimate Mortal Kombat 3. She has since become a regular ...read more.
22 Bowser - Super Mario Bros.
23 GLaDOS - Portal
24 Hades - Kid Icarus: Uprising
25 Lavos - Chrono Trigger
26 Mephiles - Sonic 2006
27 M. Bison - Street Fighter
M. Bison, also known as Dictator, is a video game character created by Capcom. First introduced in Street Fighter II: The World Warrior, he is a recurring character and villain in the Street Fighter series of fighting games, acting as the primary antagonist of the series.
28 Zanza - Xenoblade Chronicles
29 Chara - Undertale
30 Dr. Andonuts - Radiation's Earthbound Halloween Hack
What is this? A demonized fan-made version of the real Dr. Andonuts from Earthbound? He wasn't a villain in any of the official Earthbound games the last time I checked. (although he created the Ultimate Chimera and affiliated with the Pigmask Army against his will in Mother 3)
31 Chairman Drek - Ratchet & Clank
Ultimate Supreme Executive Chairman Drek (simply known as Chairman Drek) is the head of the Blarg species and the main antagonist of the 2002 videogame Ratchet & Clank and a major antagonist of the 2016 animated feature film and Playstation 4 game.
32 Sephiroth - Final Fantasy VII
33 Shodan - System Shock
34 Shadow - Sonic The Hedgehog
35 Ballos - Cave Story
36 The Doctor - Cave Story
37 Gaster - Undertale
38 Majora - Majora's Mask
39 Fawful - Mario & Luigi
Fawful, known in Japan as Gerakobits, is a fictional character appearing in the Mario & Luigi series of role-playing video games developed by AlphaDream.
40 Spy - Team Fortress 2
41 Scorpion - Mortal Kombat
Scorpion is a recurring player character and occasional boss character from the Mortal Kombat fighting game franchise created by Ed Boon and John Tobias. His debut is in the first Mortal Kombat game.
42 Gary Smith - Bully
43 Vergil - Devil May Cry
44 Elder Princess Shroob - Mario & Luigi: Partners in Time
45 Flowey (Asriel) - Undertale
46 Liquid Snake - Metal Gear Solid
47 Blood Falcon - F-Zero
48 Black Shadow - F-Zero
49 Metal Sonic - Sonic CD
Metal Sonic is one of Eggman’s fastest and most powerful creations. Programed to be better than Sonic in any aspect possible, he can shoot electro balls, shoot electricity downward, do a boost, and make himself invincible. He fight’s Sonic each time he gets stronger, and when he gains enough power, ...read more.
50 Wario - Super Mario Bros.