1 Tails and Knuckles - Sonic the Hedgehog
2 Shulk and Reyn - Xenoblade Chronicles
"I'M REALLY FEELING IT! "
"YEAH, SHULK, GET STUCK IN! "
"I GOT THROUGH THAT PRETTY GOOD! "
"NOW IT'S REYN TIME! "
"THIS IS A GOOD RESULT! "
"YEAH, GET IN THERE! " - xandermartin98
3 Alphys and Undyne - Undertale
People have been arguing for an unfathomably long time now about which of these two is a better character, but after writing Alphys VS Undyne, I can pretty much confirm that the two of them are equally awesome - xandermartin98
4 Shang Tsung and Shao Kahn - Mortal Kombat
5 Clank and Ratchet - Ratchet & Clank
6 Meta Knight and King Dedede - Kirby
7 Waluigi and Wario - Super Mario Bros.
8 Bentley and Murray - Sly Cooper
9 Sonic and Knuckles - Sonic the Hedgehog
10 Ganondorf and Beast Ganon - The Legend of Zelda
11 Ornstein and Smough - Dark Souls
12 Duster and Kumatora - Mother 3
13 Shang Tsung and Goro - Mortal Kombat
14 Darkseid and Shao Kahn - Mortal Kombat vs DC Universe
15 Peter Puppy and Jim - Earthworm Jim
16 Sans and Papyrus - Undertale
17 Luigi and Mario - Super Mario Bros.
18 Bowser Junior and Bowser - Super Mario Bros.
19 Robin and Ike - Fire Emblem
20 Citan and Fei - Xenogears
21 Fawful and Midbus - Mario & Luigi: Bowser's Inside Story
22 Cortex and Crash - Crash Twinsanity!
23 Coco and Crash - Crash Bandicoot
24 Lucca and Robo - Chrono Trigger
25 Frog and Crono - Chrono Trigger
26 Porky and Masked Man - Mother 3
27 Porky and Giygas - Earthbound
28 Gandrayda and Ghor - Metroid Prime 3: Corruption
29 Popple and Rookie - Mario & Luigi: Superstar Saga
30 Professor Monkey-For-A-Head and Psycrow - Earthworm Jim
31 Shadow and Omega - Sonic the Hedgehog
32 Black Shadow and Blood Falcon - F-Zero
33 Zoda and Black Shadow - F-Zero: GP Legend
34 Andy and Max - Advance Wars
35 Cole and Henry - Henry Hatsworth in the Puzzling Adventure
36 Lucca and Crono - Chrono Trigger
37 Lucas and Flint - Mother 3
38 Toriel and Asgore - Undertale
39 Sly and Murray - Sly Cooper
40 Dimitri and Muggshot - Sly Cooper
41 Cortex and Uka-Uka - Crash Bandicoot
42 Chairman Drek and Captain Quark - Ratchet & Clank
43 Pinstripe and Koala Kong - Crash Bandicoot
44 Medic and Heavy - Team Fortress 2
45 Eggman and Time Eater - Sonic Generations
46 Queen Zeal and Lavos - Chrono Trigger
47 Dr. Andonuts and Varik - Radiation's Halloween Hack
48 Shanoa and Albus - Castlevania: Order of Ecclesia
49 Jeff and Ness - Earthbound
50 Marth and Ike - Fire Emblem