Best Cartoons with Teenagers as Protagonists

The Top Ten
1 Steven Universe Steven Universe is an American animated television series created by Rebecca Sugar for Cartoon Network. The show's based around a young boy by the name of Steven Universe, who is a hybrid of a gem and a human. He lives with his gem friends, Garnet, Amethyst and Pearl.
2 Hi Hi Puffy Amiyumi Hi Hi Puffy AmiYumi is an American-Japanese animated fantasy-comedy television series created by Sam Register for Cartoon Network.
3 Teen Titans Teen Titans is an American animated television series created by Glen Murakami, based on the DC Comics characters of the same name.
4 Danny Phantom Danny Phantom is an American animated series created by Butch Hartman for Nickelodeon. It was produced by Billionfold Studios and distributed in Canada by Nelvana, a Canadian animation company. The series follows a teenage boy who, after an accident with an unpredictable portal between the human world ...read more.
5 American Dragon: Jake Long American Dragon: Jake Long is an American animated television series. It was produced by Walt Disney Television Animation and created by Jeff Goode.
6 Braceface Braceface is a Canadian/American animated series that aired on Teletoon in Canada, and on Disney Channel and ABC Family in the United States, as well as Fox Kids and then Pop Girl in the United Kingdom.

This deals with serious issues.

7 Kim Possible Kim Possible is an American animated children's television series created by Bob Schooley and Mark McCorkle for Disney Channel.

Should be higher

8 Star vs. the Forces of Evil "Star vs. the Forces of Evil" is an American animated television comedy produced by Disney Television Animation for Disney XD. It was created by Daron Nefcy and developed by Jordana Arkin and Dave Wasson. The series follows teenage magical princess from the dimension of Mewni Star Butterfly and her ...read more.
9 Avatar: The Last Airbender Avatar: The Last Airbender is an American animated television series that aired for three seasons on Nickelodeon from 2005 to 2008. Avatar: The Last Airbender is set in an Asiatic-like world in which some people are able to manipulate the classical elements by use of psychokinetic variants of Chinese ...read more.
10 Adventure Time Adventure Time is an American animated television series created by Pendleton Ward for Cartoon Network. The series follows the adventures of a boy named Finn (voiced by Jeremy Shada) and his best friend and adoptive brother Jake (voiced by John DiMaggio)—a dog with the magical power to change shape ...read more.
The Contenders
11 Totally Spies Totally Spies! is a French-Canadian animated spy comedy television series created by Vincent Chalvon-Demersay and David Michel and produced by Marathon Media Group and Image Entertainment Corporation.
12 Storm Hawks
13 Clone High
14 Kappa Mikey Kappa Mikey is an American animated sitcom created by Larry Schwarz. The show is Nicktoons Network's first original half-hour series, bought during the same period as other Animation Collective series such as Three Delivery and Speed Racer: The Next Generation, as well as Flash shows from other studios, ...read more.
15 Detentionaire
16 6teen 6teen is a Canadian animated sitcom originally produced by Nelvana, with the final season produced by Fresh TV. It premiered on November 7, 2004 on Teletoon.
17 Martin Mystery Martin Mystery is a French-Italian-Canadian animated television series based on the Italian comic book Martin Mystère
18 Horseland
19 Liberty's Kids
20 Amphibia Amphibia is an American animated television series created by Matt Braly that aired on Disney Channel from June 17, 2019 to May 14, 2022.
21 The Loud House The Loud House is an American animated television series created by Chris Savino for Nickelodeon. The series revolves around the chaotic suburban everyday life of a boy named Lincoln Loud and his ten sisters, to which he survives as the middle child and only son in a large family of eleven children. Originally set to premier on January 2016, the series instead premiered on May 2, 2016, with the episodes Left in the Dark and Get the Message.

Personally I think the fact that there is a familly of one boy and ten girls as children is a really creative idea.

22 Station Zero Station Zero is an American animated television series that was part of MTV's Oddities series, airing in the late 1990s. The show features a group of teenagers who run a pirate television station and find themselves in various adventures. Known for its alternative, urban aesthetic and underground music, the series appealed primarily to a young adult audience. Station Zero was praised for its unique art style and subversive themes but had a brief run.
23 The Owl House The Owl House is an American animated fantasy television series created by Dana Terrace that premiered on Disney Channel on January 10, 2020. The series stars the voices of Sarah-Nicole Robles, Wendie Malick, Alex Hirsch, Tati Gabrielle, Issac Ryan Brown, Mae Whitman, Cissy Jones, Matthew Rhys, Zeno Robinson, and Fryda Wolff.
24 Daria
25 Winx Club Winx Club is an Italian animated television series directed, created and produced by Iginio Straffi and his company Rainbow S.r.l.
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