Top Ten Female Villains In Video Games

The Top Ten
1 Mileena (Mortal Kombat) Mileena is a character from the Mortal Kombat franchise who debuted in the sequel Mortal Kombat II as a clone of Kitana by Shang Tsung using Tarkatan DNA resulting in her mouth having razor sharp teeth that of a Tarkatan like Baraka, she hated her sister Kitana and vowed to destroy her and take over her identity.

A very sick female

Just the best

2 Lusamine (Pokemon Sun and Moon) Lusamine is a fictional character introduced in Pokémon Sun and Moon. She is the head of the Aether Foundation.

Reminds me of handsome jack a misunderstod person where her children betrey her and she trys to get power by relying on a Non human power and is also some what of a psychotic person

Oh, she's DEFINITELY my favorite female video game villain as of right now.

I wouldn't call her a villain, but I like her

She look like an cool girl!

3 Mz. Ruby (Sly Cooper)
4 Harley Quinn (Batman: Arkham series) Harley Quinn is a fictional character appearing in American comic books published by DC Comics, commonly as a sidekick of the Joker.
5 Contessa (Sly 2)
6 Courtney Gears (Ratchet & Clank 3: Up Your Arsenal)
7 Maia Acheron (Jak and Daxter: The Precursor Legacy)
8 Sniper Wolf (Metal Gear Solid / Metal Gear Solid: The Twin Snakes)

One of the best Metal Gear characters and in video games overall. Great backstory to the character and I love the look of her. Menacing and compassionate.

9 Poison Ivy (Batman: Arkham Series)
10 Kreia (Star Wars Knights of the Old Republic II: The Sith Lords)

Master of deception and manipulation with deep knowledge of the sith and the jedi.

Great villain and character. And the game is really good.

The Contenders
11 Dark Queen (Battletoads)
12 Queen Slug-for-a-butt (Earthworm Jim)
13 GLaDOS (Portal series)

A perfect killer ever!

14 Gruntilda (Banjo-Kazooie) Gruntilda Winkybunion often referred to as "Grunty" is the main antagonist of the Banjo-Kazooie series debuting in the first Banjo-Kazooie game in 1998.
15 The Boss (Metal Gear Solid 3: Snake Eater)

She is NOT a villain if you've seen the ending.

16 Alma (Ninja Gaiden 2004)
17 Mui Lin (Rise to Honor)
18 Mother Brain (Metroid)

I didn't know she even had a gender.

19 Junko Enoshima (Dangan Ronpa) Junko Enoshima (江ノ島 盾子 Enoshima Junko), is a student in Hope's Peak Academy's Class 78th, and a participant of the Killing School Life featured in Danganronpa: Trigger Happy Havoc. Her title is Ultimate Fashionista/True Ultimate Despair

She is the queen of despair and will torture every inch of humanity and would do anything just to deepen her own despair

20 Sorceress (Spyro: Year of the Dragon)
21 Queen Sectonia (Kirby: Triple Deluxe)

The best part is that in her backstory, she became so vain and obsessed with conquering the lower world, because the Dimension Mirror from Kirby: The Amazing Mirror corrupted her just by her looking at it. It slowly began to transform her mind from a sweet little arachnid, into a hollow tyrannical exoskeleton of her former self.

I love her boss track and I'm big fan of Queen Sectonia she is my favorite Kirby Villain I wish she'll be in Smash Ultimate with Jibanyan, Crash, Sora, Spyro & 2 of Jibanyan's Echo fighters Komasan and Usapyon

22 Sarah Kerrigan (StarCraft series)

Responsible for millions of deaths, strong, sexy, weird and powerful an Adult villian not an Anime baby villian harming Pokemons or something. The Queen of Blades, she will slaughter your planet how is she number 10 smfh

23 Katherine Marlowe (Uncharted 3: Drake's Deception)
24 Shodan (System Shock series)
25 Alexia Ashford (Resident Evil Code: Veronica)
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