For those of you that don't know the term "Fish out of water" is where usually the main character is taken out of their comfort zone and placing them in unfamiliar territory.
The Top Ten
1Invader ZIMInvader Zim is an American animated television series created by Jhonen Vasquez for Nickelodeon. The series centers on an extraterrestrial named Zim from the planet Irk, and his mission to conquer Earth and enslave the human race along with his malfunctioning robot servant GIR.
This show is awesome, and is the best. - EliHbk
2Star vs. the Forces of EvilStar vs. the Forces of Evil is an American animated television comedy produced by Disney Television Animation for Disney XD. It was created by Daron Nefcy and developed by Jordana Arkin and Dave Wasson. The series follows teenage magical princess from the dimension of Mewni Star Butterfly and her teenage ...read more.
3FuturamaFuturama is an American animated science fiction sitcom created by Matt Groening for the Fox Broadcasting Company.
4My Life as a Teenage RobotMy Life as a Teenage Robot is an American animated science fantasy television series created by Rob Renzetti for Nickelodeon.
I remember this show, it was really awesome. A lot of nostalgia from this. - EliHbk
5Avatar: The Last AirbenderAvatar: The Last Airbender is an American animated television series that aired for three seasons on Nickelodeon from 2005 to 2008. Avatar: The Last Airbender is set in an Asiatic-like world in which some people are able to manipulate the classical elements by use of psychokinetic variants of Chinese ...read more.
Aang is a kid who was frozen in ice for 100 years awakens to find the world he once knew gone, all of the other airbenders have been wiped out by the fire nation and the world torn apart by war. - egnomac
6Drawn TogetherDrawn Together is an American adult animated sitcom which ran on Comedy Central from October 27, 2004 to November 14, 2007. The series was created by Dave Jeser and Matt Silverstein, and uses a sitcom format with a TV reality show setting.
8 cartoon characters from different universes being forced to live together in one house and all the hilarity and chaos that follows. - egnomac
7Sonic XSonic X is a Japanese anime television series created by TMS Entertainment and based on the Sonic the Hedgehog video game series published by Sega.
8We Bare BearsAn animated comedy show by Daniel Chong about three different species of bears - Grizzly, Panda and Ice bear (polar bear). Since they were little, they wanted to get adopted by owners separately. But then they missed each other too much, so they reunited again. Now as adults, they now live in a cave ...read more.
9What Ever Happened to Robot Jones
10My Gym Partner's a MonkeyMy Gym Partner's a Monkey is an American animated television series that was created by Tim Cahill and Julie McNally Cahill and produced by Cartoon Network Studios.
By some cruel fate a mix up sends Adam Lyon to an all animal school. - egnomac
11Steven UniverseSteven Universe is an American animated television series created by Rebecca Sugar for Cartoon Network. The show's based around a young boy by the name of Steven Universe, who is a hybrid of a gem and a human. He lives with his gem friends, Garnet, Amethyst and Pearl.
Peridot and Lapis do fit in the "fish out of water" category, and also to some extent Pearl.
12Dragon Ball ZDragon Ball Z is a Japanese anime television series produced by Toei Animation. Dragon Ball Z follows the adventures of Goku who, along with the Z Warriors, defends the Earth against evil. The action adventures are entertaining and reinforce the concept of good versus evil. Dragon Ball Z teaches valuable ...read more.
13Planet SheenPlanet Sheen is an American CGI animated television series. It is a spinoff series in the Jimmy Neutron franchise, focusing on the show's comic relief, Sheen Estevez, as he gets stranded on another planet. The show was hated by critics and fans for not using any of the original cast (besides the obvious), ...read more.
14Adventure TimeAdventure Time is an American animated television series created by Pendleton Ward for Cartoon Network. The series follows the adventures of a boy named Finn (voiced by Jeremy Shada) and his best friend and adoptive brother Jake (voiced by John DiMaggio)—a dog with the magical power to change shape ...read more.
15Gravity FallsGravity Falls is an American animated television series produced by Disney Television Animation that first aired on Disney Channel, and then on Disney XD from June 15, 2012 to February 15, 2016. The series follows the adventures of Dipper Pines and his twin sister Mabel in the fictional town of Gravity ...read more.