1 Purple Guy (Five Nights at Freddy's)
2 Bowser (Mario Bros. Series)
Bowser is the main antagonist of the Mario Bros. Franchise. From kidnapping Princess Peach to simply destroying a fun game between Mario and Friends in the Mario Party spinoff series, this king of the Koopas has set up a certain hatred towards himself amongst the large cast of Mario Characters. He first ...read more.
I can't imagine Super Mario without Bowser. He's just a classic villain. - Garythesnail
Bowser is the only male in the series
3 Dr. Eggman (Sonic the Hedgehog)
Doctor Ivo "Eggman" Robotnik is a fictional video game character and the main antagonist of the Sonic the Hedgehog series, created by Sega.
Although I do not like his name, it is a major villain
4 Master Hand (Super Smash Bros.)
He is a classic
5 Dr. Wily (Mega Man)
Doctor Wily, full name Albert W. Wily, is a video game character and the main antagonist of the original Mega Man series.
6 King Dedede (Kirby)
King Dedede is a fictional character and the primary antagonist of the Kirby series of video games owned by Nintendo and HAL Laboratory.
Wouldn't be the same without him. Even though he hasn't been ill-intentioned lately, he's still one of my favorite characters. - Garythesnail
7 Slender Man (Slender: The Eight Pages)
8 The Joker (Batman: Arkham Series)
The Joker is a fictional super villain created by Bill Finger, Bob Kane, and Jerry Robinson who first appeared in the debut issue of the comic book Batman (April 25, 1940) published by DC Comics . Credit for the Joker's creation is disputed; Kane and Robinson claimed responsibility for the Joker's design, ...read more.
9 Ganondorf (The Legend of Zelda Series)
Ganon (Referred to as Ganondorf in human form) is a fictional character and the central antagonist of Nintendo's Legend of Zelda series. He is a power-hungry Gerudo who possesses the Triforce of Power and aims to conquer Hyrule with the remaining Triforce parts.
10 Andross (Star Fox)
11 Doctor Neo Cortex (Crash Bandicoot)
12 GLaDos (Portal)
GLaDOS is a fictional artificially intelligent computer system appearing in the video games Portal and Portal 2. The character was created by Erik Wolpaw and Kim Swift and voiced by Ellen McLain.
13 Xehanort (Kingdom Hearts)
Xehanort is a fictional character and the true primary antagonist of the video game crossover series Kingdom Hearts by Tetsuya Nomura.
14 Ghirahim (The Legend of Zelda: Skyward Sword)
15 Clockwerk (Sly Cooper)
16 Kefka Palazzo (Final Fantasy VI)
17 Dr. Nefarious (Ratchet & Clank)
18 Dracula (Castlevania)
19 The Empire (Grandia)
20 Zanza (Xenoblade Chronicles)