Hardest The Binding of Isaac BossesWopwop
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Honestly one of the hardest and most annoying bosses, from his peepers to his moves being cheap shots with brimstone, crashing down with creep, and a radical pattern of blood shots, he is just my least favorite boss.
Even though this one is extremely difficult, It is my favorite boss. - Lick_JJ
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2. Mask of Infamy