Hardest The Binding of Isaac Bosses

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The Top Ten

1 Mom
2 Isaac
3 Bloat

Honestly one of the hardest and most annoying bosses, from his peepers to his moves being cheap shots with brimstone, crashing down with creep, and a radical pattern of blood shots, he is just my least favorite boss.

Even though this one is extremely difficult, It is my favorite boss. - Lick_JJ

4 Gurdy
5 Pestilence Pestilence Pestilence were a death metal band from the Netherlands founded in 1986. They are known for incorporating jazz and fusion elements into their music.
6 Mask of Infamy
7 Delirium
8 Hush
9 It lives
10 Mega Maw

The Contenders

11 Satan
12 The Cage
13 Adversary
14 The Haunt
15 Rag Mega
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