Hardest The Binding of Isaac BossesWopwop
The Top Ten
Honestly one of the hardest and most annoying bosses, from his peepers to his moves being cheap shots with brimstone, crashing down with creep, and a radical pattern of blood shots, he is just my least favorite boss.
Even though this one is extremely difficult, It is my favorite boss. - Lick_JJ
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2. Mask of Infamy