Hardest The Binding of Isaac Bosses

The Top Ten Hardest The Binding of Isaac Bosses

1 Bloat

Honestly one of the hardest and most annoying bosses, from his peepers to his moves being cheap shots with brimstone, crashing down with creep, and a radical pattern of blood shots, he is just my least favorite boss.

Even though this one is extremely difficult, It is my favorite boss. - Lick_JJ

2 Mom
3 Isaac
4 Gurdy
5 Pestilence Pestilence is a death metal band from the Netherlands founded in 1986. They are known for incorporating jazz and fusion elements into their music.
6 Delirium
7 Mask of Infamy
8 Hush
9 It lives
10 Mega Maw

The Contenders

11 Satan
12 Adversary
13 The Cage
14 Rag Mega
15 The Haunt
16 Polycephalus
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