Top Ten Best Items In The Binding of Isaac: Rebirth

The Top Ten Best Items In The Binding of Isaac: Rebirth

Brimstone

The damage to every enemy is crazy

Awesome Item, has a lot of good qualtities

Easily the best. Amazing synergies, excels at clearing rooms and destroying bosses, and has unlimited range.

Mom's Knife

good

A single damage up with this item allows for rapid destruction when using it as melee.

Godhead

worth it

Hard to unlock but is worth it

Polyphemus
Holy Mantle
Sacred Heart
20/20
Stop Watch

Not anymore it isn't.

It's still really good, especially when fighting a boss like Ultra Greed, Hush or Delirium

Magic Mushroom

Great to get at the start of a game

The Book of Belial

The increased chance of devil rooms is great

The Contenders

The Pinking Shears
Epic Fetus
Cricket's Head
Abaddon
The D6
Death's Touch
Dark Bum
Mutant Spider
Ceremonial Robes
Ipecac
The Pact
The Mark
The Small Rock
Bumbo

All hail Bumbo

Incubus
The Ludovico Technique
The Wafer
Capricorn
Pyromaniac
Daddy LongLegs
Humbleing Bundle
Contract From Below
Proptosis
Trinity Shield
The Soul
The Mind
The Body
The Inner Eye
Squeezy
Synthoil
Pentagram
Growth Hormones
Money = Power
Blood of the Martyr
SMB Super Fan
Goat Head
Cricket's Body
The Halo
Skeleton Key
Mom's Contacts
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