Top Ten Best Items In The Binding of Isaac: Rebirth

The Top Ten

1 Brimstone

Easily the best. Amazing synergies, excels at clearing rooms and destroying bosses, and has unlimited range. - Lanturnizer6

2 Godhead

Hard to unlock but is worth it

3 Sacred Heart
4 20/20
5 Mom's Knife

A single damage up with this item allows for rapid destruction when using it as melee.

6 Holy Mantle
7 Epic Fetus
8 Polyphemus
9 Crown of Light
10 Dark Bum

The Contenders

11 Stop Watch

Not anymore it isn't.

It's still really good, especially when fighting a boss like Ultra Greed, Hush or Delirium - Lanturnizer6

12 The Pinking Shears
13 Abaddon
14 The D6
15 The Book of Belial
16 Incubus
17 The Ludovico Technique
18 Magic Mushroom
19 Cricket's Head
20 Death's Touch
21 The Wafer
22 Capricorn
23 Pyromaniac
24 Mutant Spider
25 Daddy LongLegs
26 Ceremonial Robes
27 Ipecac
28 Humbleing Bundle
29 Contract From Below
30 The Pact
31 The Mark
32 The Small Rock
33 Proptosis
34 Trinity Shield
35 The Soul
36 The Mind
37 The Body
38 The Inner Eye
39 Squeezy
40 Synthoil
41 Pentagram
42 Growth Hormones
43 Money = Power
44 Blood of the Martyr
45 SMB Super Fan
46 Goat Head
47 Cricket's Body
48 The Halo
49 Skeleton Key
50 Mom's Contacts
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