Spider-Man is a fictional superhero appearing in American comic books published by Marvel Comics existing in its shared universe.
Himself, the awesome web slinger. - villainlover
It's his own franchise
I love Spiderman
Carnage (Cletus Kassidy) is a fictional supervillain appearing in American comic books published by Marvel Comics, usually as an enemy of Spider-Man.
Arch rival of Venom. - villainlover
Venom, or the Venom Symbiote, is an alias used by several fictional characters appearing in American comic books published by Marvel Comics, commonly in association with Spider-Man.
4 Doc Oc
5 Green Goblin/Norman Osborn
I'm so in love with Greenie that I've married him...
He hates Spider man.
Norman Osborn hands down. - villainlover
6 Emperor Venom
Okay, I made up about the Emperor part. But Venom himself is the best! He nearly killed the web-slinger! He is the most awsome enemy of Spider man! - villainlover
Boss of Peter Parker. - villainlover
The design of him is a massive success. - villainlover
One of the most dangerous villains ever. - villainlover
10 The Lizard
11 Harry Osborn/Green Goblin
The web slinger's former friend and enemy - villainlover
Better suit, better powers than his father. but he died... R.I.P sweet goblin jr
12 Mary Jane Watson
Mary Jane "MJ" Watson-Parker is a fictional character, a supporting character appearing in American comic books published by Marvel Comics.
13 The Vulture
Mysterio is a fictional supervillain appearing in American comic books published by Marvel Comics. He is most often depicted as an enemy of Spider-Man.
Best Spider-Man Villain ever! - asantalo
18 Gwen Stacy
Gwendolyne Maxine "Gwen" Stacy is a fictional character who appears in American comic books published by Marvel Comics, usually as a supporting character in those featuring Spider-Man.
20 Uncle Ben
22 Black Cat
23 Miles Morales
Miles Morales is a fictional character appearing in Marvel Comics. He is the Marvel Ultimate Universe's Spider-Man after Peter Parker died.
24 Scarlet Spider
Have you seen the things this spider can do.
29 Mr. Negative
The Sandman first appeared in The Amazing Spider-Man #4 (Sept. 1963), created by writer Stan Lee and artist Steve Ditko as an adversary of Spider-Man. The character returned in The Amazing Spider-Man #18 and #19, and was soon depicted in other comics, such as The Incredible Hulk and The Fantastic Four. ...read more.
31 Aunt May
Aunt May is a fictional character appearing in American comic books published by Marvel Comics. Created by writer Stan Lee and artist Steve Ditko, the character made her first appearance in Amazing Fantasy #15.
32 Kraven the Hunter