Things That Differentiate Fullmetal Alchemist from Fullmetal Alchemist Brotherhoodegnomac
The Top Ten
The story except for the beginning is entirely different. - Kiteretsunu
There's a lot more going on in brotherhood
The Original Fullmetal Alchemist's villain is Lady Dante and Brotherhoods main villain is Father. - egnomac
Only 2 filler episodes in Brotherhood
FM Sloth is Ed & Al's dead mother who they tried to bring back with alcemy, Brotherhood Sloth is this Large bulking monster. - egnomac
King Bradley was pride in this one and wrath in the brotherhood one.
FM Wrath was Izumi's child who she tried to bring back to life through Alchemy, BH King Bradley is secretly the Hummuncolis Wrath. - egnomac
Mustang was the one who murder's winry parents by order in the first version and in brotherhood It was revealed that Scar was the one who murdered them in a blind rage. - egnomac
In the 2003 version he was a guy but in Brotherhood he's genderless
In FMA, Barry kidnaps Winry in the beginning and lures in Ed. In FMAB, Barry is a soul bonded to a suit of armor.
Brotherhood's only missed opportunity.
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2. The Main Villain
3. Brotherhood Most Closely Follows the Manga