Top 10 Best TV Animated Villains of the 2000s and 2010s

The Top Ten
1 Bill Cipher - Gravity Fall Bill Cipher is a triangular dream demon formerly existent only in the mindscape who wished to gain access to the real world. He has been running amok in Gravity Falls, Oregon since being summoned by Stanford Pines over thirty years ago. He is known for his mysterious demeanor and sadistic humor. He is the main antagonist of Gravity Falls, although he doesn't play a central role in the series until season 2.
2 Aku - Samurai Jack Aku is a fictional character and the main antagonist of Samurai Jack, an American animated television series created by Genndy Tartakovsky for Cartoon Network.
3 Zaheer - The Legend of Korra

Possibly the biggest threat in The Legend of Korra series as the leader of the Red Lotus who acquires Airbending following Harmonic Convergence which allowed him to escape and free the other members and pursue their goal of ridding the world of leaders, kings/queens and the Avatar and he succeeds for the most part after killing off the Earth Queen by using his airbending to suck the air from her lungs and leaving her to suffocate to death and nearly kills off Korra by poising her and tried to force her into the avatar state to not only kill her but also end the entire Avatar cycle forever.

4 Slade - Teen Titans Slade is a fictional incarnation of the character Deathstroke in the American animated series Teen Titans and is the archenemy of the Teen Titans, who wants them destroyed for his own unknown reasons, and is the main antagonist of Season 1 and Season 2; He appears as a vision in Season 3, returned only as a loyal and devoted minion of the mighty demon Trigon in Season 4, he also makes a small appearance in the final episode of Season 5 "Things Change." He also appears as the main antagonist of Teen Titans Go to the Movies. He was voiced by Ron Perlman and Will Arnett. He is also the arch-nemesis of Robin.
5 Father - Full Metal Alchemist: Brotherhood

Main villain of FMA Brotherhood who seeks to sacrifice the chosen few as well as the Amestrians in order to obtain the power of god

6 The Lich - Adventure Time The Lich (formerly named the Lich King in the original pitch and "His Hero," and referred to as Sweet Pig Trunks in his baby form, or just Sweet P for short) is a powerful undead being and a major antagonist in the American animated series Adventure Time.
7 Marik Ishtar - Yu-Gi-Oh

Possibly one of the best Yu-Gi-Oh villains in anime.

8 Aquamarine - Steven Universe
9 Fire Lord Ozai - Avatar the Last Airbender

An all out dangerous villain who looks to use the power from Sozin's comet which enhances a fire bender's power so he can burn the entire city of Ba Sing Se to the ground killing millions of people in the process.

10 Lysandre - Pokemon XYZ the Series
The Contenders
11 Azula - Avatar: The Last Airbender Princess Azula is a fictional character and antagonist of Nickelodeon's animated television series Avatar: The Last Airbender. She is voiced by Grey DeLisle Griffin.
12 Ice King - Adventure Time The Ice King is a character in the American animated television series Adventure Time. A supposedly evil wizard capable of creating and manipulating ice and snow, he is the self-proclaimed king of the Ice Kingdom, a land of ice he claimed as his own and lives in in company of many penguins.
13 Sideshow Bob - The Simpsons Dr. Robert Underdunk Terwilliger, better known as Sideshow Bob, is a recurring character in the animated television series The Simpsons.
14 Vilgax - Ben 10 Vilgax is a fictional character and one of the main antagonists of the American animated TV series and media franchise Ben 10 created by Man of Action Studios and produced by Cartoon Network Studios.
15 Negaduck - Darkwing Duck
16 Earl of Lemongrab - Adventure Time
17 Cornelia - Code Geass
18 Him - The PowerPuff Girls
19 Queen Beryl - Sailor Moon
20 Vlad Plasmius - Danny Phantom Vladimir "Vlad" Masters (also known as Vlad Plasmius) is the main antagonist from the American animated series Danny Phantom created by Butch Hartman for Nickelodeon. He is Danny's arch-enemy and Jack Fenton's former best friend and Maddie's former lover. He is voiced by Martin Mull.
21 Dr. Blowhole - Penguins of Madagascar
22 Skeletor - He-Man and the Masters of the Universe Skeletor is a fictional character and the main antagonist of the Masters of the Universe franchise created by Mattel.
23 Shocker - The Spectacular Spider-Man
24 Mandark - Dexter's Laboratory Susan "Mandark" Astronomanov is the main antagonist in the American animated series Dexter's Laboratory. He is Dexter's rival and later mortal nemesis who often seeks to destroy both Dexter and his lab to prove once and for all that he is the superior genius. He is voiced by Eddie Deezen.
25 Diane Simmons - Family Guy
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