1 Psycho Mantis (Metal Gear Solid)
2 Sinistar (Sinistar)
3 Kain (Soul Reaver)
4 Kerrigan (Starcraft)
The Queen of Blades is a badass and a Manipulator who manipulated The Terran and the protoss in the brood war And crippling them! - Aguythatpeopleignores
5 Dr. Breen (Half Life 2)
6 SHODAN (System Shock 2)
7 M. Bison (Street Fighter)
M. Bison, also known as Dictator, is a video game character created by Capcom. First introduced in Street Fighter II: The World Warrior, he is a recurring character and villain in the Street Fighter series of fighting games, acting as the primary antagonist of the series.
8 Goro (Mortal Kombat)
Goro is a fictional character from the Mortal Kombat fighting game series. He first appears in the original Mortal Kombat as an unplayable boss character, challenging the player before the final fight with Shang Tsung.
9 Ganondorf (Legend Of Zelda)
Ganon (Referred to as Ganondorf in human form) is a fictional character and the central antagonist of Nintendo's Legend of Zelda series. He is a power-hungry Gerudo who possesses the Triforce of Power and aims to conquer Hyrule with the remaining Triforce parts.
10 Alma (F.E.A.R)
Alma Wade is a major antagonist and key figure in the F.E.A.R. series of first-person shooter horror video games by Monolith Productions, introduced in F.E.A.R. in 2005. The plot of the series revolve around the mystery of Alma.
11 Shao Kahn (Mortal Kombat)
Shao Kahn is a boss, announcer, and recurring playable character from the Mortal Kombat fighting game series. Introduced in Mortal Kombat II in 1993, he is the primary antagonist of the video game series and extended franchise.
12 Old Crow (Timsplitters: Future Perfect)
13 Pyramid Head (Silent Hill)
14 Bowser (Super Mario Bros.)
Bowser is the main antagonist of the Mario Bros. Franchise. From kidnapping Princess Peach to simply destroying a fun game between Mario and Friends in the Mario Party spinoff series, this king of the Koopas has set up a certain hatred towards himself amongst the large cast of Mario Characters. He first ...read more.
15 Mecha-Hitler (Wolfenstein 3D)
16 Cyberdemon (DOOM)
The Cyberdemon is a fictional character in the Doom gaming-franchise by id Software, where it was introduced in the first-person shooter game Doom in 1993. Since then, it has appeared in several other id games, including all main-line Doom sequels, Doom RPG, and Wolfenstein RPG as the Harbinger of Doom, ...read more.
17 Mike Tyson (Mike Tyson's Punchout!)
18 Officer Tenpenny (GTA: SA)
19 Giygas (Earthbound)
20 Vladimir Makarov (COD: MW2)
21 Akuma (Street Fighter)
Akuma known as Gouki in Japan is a character of the Street Fighter series and recurring antagonist, first appearing in Super Street Fighter II Turbo as a hidden character and boss who could be summoned after certain conditions were met, an emotionless and powerful warrior fixated on mastering the Satsui ...read more.
22 Ares (God Of War)
23 Darth Malak (KOTOR)
Darth Malak is a Star Wars character. Malak is a Sith from the time of The Old Repbulic. He is the apprentice of Revan, and appears in Knights of the Old Republic
24 Nemesis (Resident Evil 3)
25 King Dedede (Kirby)
King Dedede is a fictional character and the primary antagonist of the Kirby series of video games owned by Nintendo and HAL Laboratory.
26 Olivia Pierce (DOOM)
27 Vaas Montenegro (Far Cry 3)
Vaas Montenegro is the secondary antagonist of Far Cry 3, appearing as the main antagonist for the first half of its storyline.
Vaas is the type of guy who would have a cup of tea with you and then put a bullet in between your eyes for the fun of it. He is a true sociopath! - Aguythatpeopleignores
28 Handsome Jack (Borderlands 2)
Handsome Jack is the main antagonist of both Borderlands 2 and Tales from the Borderlands and the deuteragonist of Borderlands: The Pre-Sequel.
Flowey is a flower in the RPG Undertale. He is the first character you meet, and also your best friend.
30 Nightmare (Soul Calibur)
Nightmare is an antagonist in Five Nights at Freddy's 4 and one of the seven nightmare animatronics (ten if the Halloween Edition animatronics and Plushtrap are counted) in the game. He is the shadowy incarnation of Nightmare Fredbear, and the final antagonist in the game.
31 Joker (Batman Arkham)
32 Riddler (Batman Arkham)
33 Andrew Ryan (Bioshock)
Andrew Ryan is a fictional character in the BioShock video game series developed by Irrational Games. He serves as the primary antagonist of the first half of the first BioShock and a minor character in its sequel, BioShock 2. Ryan is an idealistic business magnate in the 1940s and 1950s; seeking to ...read more.
34 Jacqueline Natla (Tomb Raider)
35 Andross (Star Fox)
36 Dormin (Shadow of the Colossus)
37 Altair (Bomberman 64)