Here it is... the most menacing, most evil and most down right nasty countdown of them all. I have included rivals as well so other cartoons that didn't necessarily have a fantasy or hero theme to them could jump in the mix. Enjoy!
1 Slade (Teen Titans)
Slade is a fictional incarnation of the character Deathstroke in the American animated series Teen Titans and is the archenemy of the Teen Titans, who wants them destroyed for his own unknown reasons, and is the main antagonist of Season 1 and Season 2; He appears as a vision in Season 3, returned only ...read more.
I always wondered, what was behind his mask... - nintendofan126
In the series had many faces but obviously is Deathstroke
2 Frieza (Dragon Ball Z)
Freeza (Pronounced "Frieza" in the Funimation dub) is fictional character in the Dragon Ball series by Akira Toriyama as the primary antagonist of the Freeza Saga. He is a galactic tyrant who governs the Planet Trade Organization and is feared by the universe for his sadistic and brutal nature. He is ...read more.
He fought like a king and died like a god
3 Chairface Chipindale (The Tick)
4 Gary Oak (Pokemon)
Gary oak appeared in the anime series in seasons 1-5 . He was ash's rival and childhood friend . Though they had a dispute once they fought over a rusty pokeball they wanted for luck, which broke after they fought over it . Gary was the grandson of professor oak . He had cheerleaders & his own car. ...read more.
5 MegaByte (ReBoot)
6 Mojo Jojo (The Powerpuff Girls)
Mojo Jojo is a fictional character from the American animated television series, The Powerpuff Girls, created by animator Craig McCracken for Cartoon Network.
The villain with the best voice in the world
There's no villain that can deliver a monologue like him
7 The Joker (Batman: The Animated Series)
The Joker is a fictional super villain created by Bill Finger, Bob Kane, and Jerry Robinson who first appeared in the debut issue of the comic book Batman (April 25, 1940) published by DC Comics. Credit for the Joker's creation is disputed; Kane and Robinson claimed responsibility for the Joker's design, ...read more.
The favorite and pro
8 Mumm-ra (Thundercats)
9 Roger Klotz (Doug)
Roger Klotz is the main antagonist of Doug. He is Doug Funnie's enemy and later friend, and often goes to great extents to bully him or make him look stupid in front of his crush, Patti Mayonnaise.
10 Dr Claw (Inspector Gadget)
He had style and wisdom
11 Queen Chrysalis (My Little Pony: Friendship Is Magic)
Queen Chrysalis is a female changeling who serves as the main antagonist for the season 2 finale of My Little Pony: Friendship is Magic.
12 Dan Phantom (Danny Phantom)
Dan Phantom is a fictional character in the American animated series Danny Phantom created by Butch Hartman for Nickelodeon.
13 The Gangreen Gang (The Powerpuff Girls)
14 Bill Cipher (Gravity Falls)
Bill Cipher is a triangular dream demon formerly existent only in the mindscape who wished to gain access to the real world. He has been running amok in Gravity Falls, Oregon since being summoned by Stanford Pines over thirty years ago. He is known for his mysterious demeanor and sadistic humor. He ...read more.
15 Cell (Dragon Ball Z)
Cell is a fictional character in the Dragon Ball series by Akira Toriyama. He is the main antagonist of the Android Saga, being an android/artificial life form from the future, whose goal is to become "perfect" via absorbing Androids 17 and 18 and becoming the strongest fighter in the universe.
16 Pacifica (Gravity Falls)
17 Shego (Kim Possible)
Shego is a fictional character from Disney's animated television series Kim Possible, voiced by Nicole Sullivan.
18 Heather (Total Drama)
19 Phobos (W.I.T.C.H.)
20 Sasuke Uchiha (Naruto)
Sasuke Uchiha is a fictional character from the manga and anime franchise Naruto, created by Masashi Kishimoto.
21 Man Ray (SpongeBob SquarePants)
22 Diamond Tiara (My Little Pony: Friendship Is Magic)
Diamond Tiara is a female school-age Earth pony and minor antagonist who first appears in Call of the Cutie. She and Silver Spoon are classmates of the Cutie Mark Crusaders.
23 Queen Beryl (Sailor Moon)
24 Dick Dastardly (Wacky Races)
25 Gargamel (The Smurfs)
Gargamel is a fictional character from The Smurfs. He is an evil wizard, the sworn enemy of the Smurfs, and the main antagonist in the show and comic books.
26 Julie (Hi Hi Puffy Amiyumi)
27 Trixie (My Little Pony: Friendship Is Magic)
Trixie Lulamoon, is a female unicorn pony and traveling magician. She tends to speak in the third person and refer to herself as "The Great and Powerful Trixie".
28 Maximus (Atomic Betty)
29 Whittany Biskit (Littlest Pet Shop)
30 Brittany Biskit (Littlest Pet Shop)
31 Skeletor (He-Man and the Masters of the Universe)
Skeletor is a fictional character and the main antagonist of the Masters of the Universe franchise created by Mattel.
32 Mandark (Dexter's Laboratory)
Susan "Mandark" Astronomanov is the main antagonist in the American animated series Dexter's Laboratory. He is Dexter's rival and later mortal nemesis who often seeks to destroy both Dexter and his lab to prove once and for all that he is the superior genius. He is voiced by Eddie Deezen.
33 Vlad Plasmius/Masters (Danny Phantom)
Vladimir "Vlad" Masters (also known as Vlad Plasmius) is the main antagonist from the American animated series Danny Phantom created by Butch Hartman for Nickelodeon. He is Danny's arch-enemy and Jack Fenton's former best friend and Maddie's former lover. He is voiced by Martin Mull.
34 Ember Mclain (Danny Phantom)
Ember McLain is a fictional character in the American animated series Danny Phantom created by Butch Hartman for Nickelodeon.
35 Cartman (South Park)
36 Dr. Doofenshmirtz (Phineas and Ferb)
37 Alejandro (Total Drama)
38 The Rowdyruff Boys (The Powerpuff Girls)
39 Anti-Cosmo (The Fairly OddParents)