Isaac Clarke is the main protagonist of the Dead Space franchise as an engineer worker who was a part of the emergency response unit of the USG Killian sent to investigate the USG Ishimura after losing contact with the crew members one of which was Isacc's girlfriend Nicole Brennan, upon their arrival they discover the USG Ishimura infested with alien like creatures known as Necromorphs as well as an ancient artifact known as the Marker which was responsible for the infestation despite Isaac's best efforts to find Nicole all his efforts were in vain as it turns out she had committed suicide long before arriving at the USG Ishimura not only that but Isaac become infected by the effects of the Marker which caused him to hallucinate images of Nicole despite escaping the planet and destroying the Marker Isaac's troubles were only just beginning as he was later found and brought aboard the Sprawl space station where yet another Necromorph out break happened not only that but Isaac's effects from the Marker continue to plague him as he is continuously haunted by the memories of Nicole.
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