Top 10 Hardest Enemies to Kill in Resident Evil 5

In Resident Evil 5, players often find themselves coming face-to-face with a range of formidable enemies, each bringing its unique set of challenges and barriers to survival. The world of this game is teeming with adversaries who can make your journey a living nightmare.
The Top Ten
Reapers

I agree that these are some of the hardest enemies, but you just need the first to third handgun to win. Stock up on at least 60 shots (including a fully loaded clip).

Run and create some distance. I shoot the left arm first, but that's just a preference of mine. Then, I wait until it falls on the other arm before shooting. Once the chest infection spore pops out of the armor, I spam my reloaded clip (I reload a lot, laugh out loud). If you miss a couple of shots (three or more), it'll be weakened but get back up.

Giant cockroaches are a lot harder than I thought - they're much worse than a chainsaw zombie in Resident Evil 5! The best way to kill this pest is by using mines or finishing it off with a Gatling gun if you have it unlocked!

Duvalia

Actually, these monsters that look like crab-like clams are Duvalias! If you're in a dying state and a Duvalia grabs you, then all that will be left of you are your legs and bottom!

You should either shoot the legs or tail of the Duvalia and then shoot the opening of the beast to terminate it!

This is actually the Majini that transforms into a big, clam-like monster with a huge mouth and a ribcage for a tail. It picks you up and eats you if you get too close.

You will die, no kidding. The only way to kill them is by shooting their annoying tail.

Licker β

These guys are a pest because if they stick their tongue in you, it's game over.

Just one touch and there's no chance to escape.

Ndesu

This is the big troll (El Gigante from RE4). Everybody claims that he is tough to beat, but he's actually not that difficult.

Learn to stop the big flying boulder he throws at you, and you should be fine.

This guy is pretty hard, laugh out loud. No healing, silly button pressing, and the computer AI is really bad (Sheva sucks). I managed to do it on my fourth attempt with co-op play - this guy is a badass.

Add turnerboythe2nd on PSN if you need help with this brute of a boss. He's easily the hardest enemy in the game. Fat Majini guys are easy compared to this troll guy on level 2.3 on Pro.

Big Man Majini

This Majini takes the form of a large, shirtless man, and if he hits you, you're in trouble.

Albert Wesker

He can be easy, challenging, or downright insanely difficult to fight, depending on how you approach the battle. You'll encounter Albert four times throughout the campaign: first in the Monarch Room, then in the Missile Facility, third inside the assault stealth bomber (in QTE style), and finally in the volcano, which is also the hardest encounter.

A word of advice: make sure you have plenty of ammo, particularly a magnum and an RPG. Also, be good at QTEs - there'll be plenty of them. Good luck!

This guy is a badass. He's really not that bad as long as you have an infinite rocket launcher. Otherwise, you'll be stuck all night.

Gatling Gun Majini

These guys carry enormous Gatling guns on their backs. On Professional difficulty, one hit puts you into dying mode, and another ends you completely.

Jill Valentine (under control)

It's a frustrating fight, especially on harder difficulties (Veteran and Professional). Jill can deal massive damage to you or your AI partner, sometimes even leaving you in a dying state.

A word of advice: try to stay away from her, then approach stealthily from behind to restrain her. Be attentive to QTEs (Quick Time Events), as you'll spend most of the time dealing with them. Make sure to stock up on health items just in case. Also, don't use a magnum or shotgun when shooting her chest device, as it can kill her, resulting in a game over. Handguns and rifles are safer and much better options. Patience is your best weapon here.

Uroboros Aheri

Don't get caught in its path, or it's curtains for you. The best way to deal with it is to hide whenever you hear it coming, and try to locate its handler. Eliminate him to get rid of this weapon.

These are in Chapter 4-2, and for some reason, I had a really rough time getting past them. I finally got my friend to blow them up with a rocket launcher.

Ricardo Irving

This is a long and grueling battle, so be prepared for it. Be patient and shoot him with either the mounted guns or rocket launchers on the boat, or just use your ammo.

However you deal with him, be wary of his tentacles and where he may pop out. Watch out for QTEs as well, and try to make him come out of the monster's mouth to deal real damage. If you have an RPG, unload one on him to finish the fight.

He can be a real pain. Make sure you have the infinite rocket launcher, and he's not that bad. No infinite rocket launcher equals no beating Irving.

The Contenders
Chainsaw Majini

This guy is so hard to kill! He is fast, and he can behead you when he gets close. The best way to kill him is with a magnum or an RPG. Land mines also help.

It is the hardest enemy to kill when you only have a shotgun.

Excella Gionne

The only way to destroy this is with the target locator. The object keeps moving before you get a chance to lock on to its weak points, and its instant kill is also really annoying.

It took longer to beat her than it did weaker opponents like Jill. She was tough.

Popokarimu
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