Top 10 Best Mass Effect Missions

The Mass Effect series has some of the most unforgettable missions in gaming, and for good reason. Each mission is designed with purpose, whether it's to deepen the lore of the universe, reveal hidden aspects of a beloved character, or push you to make decisions that might alter the entire story. Some missions pull you in with high-stakes action and tight pacing, while others provide moments of reflection and surprising emotion. From the high-octane thrill of taking on enemies that feel larger-than-life to quieter, more personal quests where you learn the backstory of your squadmates, every moment builds toward something meaningful.
The Top Ten
Collector Base: Suicide Mission

This is a mission where your choices MATTER! The first time through, I was just like, "Oh, it's going to be an epic ending, but it will be scripted." Then half my squad started dying in brutal ways. Jack got shocked to death, Legion exploded, Thane got impaled, Jacob got his head blown off, Garrus got taken by those wasps, Samara got killed, and Miranda died in my arms. By the end, I was like, "If this was real, I'd be so dead."

This is the only mission where you can have all of your squad members in combat, and crucial decisions make this mission really stand out from all the rest. Team members survive or perish depending on their loyalty, their role during the mission, and their power.

I don't think there is a flaw in this mission. Everything was great.

The Citadel DLC

I think it is the best mission in all the Mass Effect games. I laugh every time I play the Citadel DLC. I also like the fact that you can spend time with your squadmates and loved ones outside the battlefield, and the party is just epic!

By far the most enjoyable Mass Effect mission I have ever played. It has great romance scenes, great action, a great story, and the best comedy I've seen in the whole series. I wish more missions were like this.

I loved Lair of the Shadow Broker and the Suicide Mission, but the Citadel is just a bit of closure and fun after hours and hours of hardcore Mass Effect gaming. The only downside is the cost.

Lair of the Shadow Broker

A thrilling DLC from start to finish. The flying car chase was fun, and Liara unexpectedly becomes the new Shadow Broker following a great showdown with the Shadow Broker, a Yahg.

Priority: Tuchanka

This mission builds up a lot from the previous two games, and the genophage is finally cured. Or is it? Depending on Shepard's actions, you can trick the Krogans into thinking the genophage is cured to prevent Krogan expansion in the future and get them on your side in the fight against the Reapers.

Mordin also has a tragic but heroic end as he cures the genophage at the cost of his life.

"I made a mistake! I made a mistake..."

Priority: Earth

I don't despise the endings themselves and thought they had some amazing scenes with all the fleets attacking the Reapers, as well as a full look at The Illusive Man's corruption due to the Reaper Indoctrination.

The ending gives off many ideas for a sequel, so many I wouldn't want to give all of them out. The only thing that stops this mission from reaching the number one spot is that it doesn't show much of the characters during the battle and their fate. The ending could have added scenes of where all of your former squadmates and allies were during Shepard's decision. Perhaps a glimpse of the Citadel after the dust settled would have been good.

Ilos

This is when things start to get BIG. You successfully defeat Saren following a tough climax. The soundtrack was amazing, and the decision to save the council or not was great, especially at the time. The ending made me feel excited about what will come next.

Virmire

It has one of the best decisions in the trilogy and also an interesting confrontation with Wrex.

I didn't vote for this, but to be fair, finally being able to get rid of Wrex is very cathartic.

Overlord
Priority: Rannoch

Do you take the Quarians or take the Geth and allow Tali to die? Or take both if you have high enough Paragon/Renegade points.

Dossier: Archangel
The Contenders
Leviathan

This DLC has its flaws and doesn't give a lot of information about the Leviathans themselves or how the "Intelligence" overthrew them. However, the basic plotline is interesting. With this information, it may be safe to speculate that the Leviathans may make an appearance in Mass Effect 4, perhaps rising again?

Priority: Thessia
Omega
Kasumi: Stealing Memory
Race Against Time
Priority: The Citadel II
Find Liara T'Soni

It's the first time we meet Liara. I like it because it feels like a romantic rescue.

Thane: Sins of the Father
Collector Ship
Priority: Cerberus Headquarters
Reaper IFF
Noveria
Dossier: The Convict

A great battle mission with a lot of thrills, and it introduces a great squadmate: Jack.

Rannoch: Geth Fighter Squadrons
Eden Prime: Prologue
8Load More
PSearch List