OK, shows can have multiple main characters, but for this list I'm specifically talking about ones where there are two or more main protagonists. Like for example, SpongeBob has multiple main characters, but the true protagonists is SpongeBob himself. Compare that to shows like Tom and Jerry or Drake & Josh where there are two true protagonists and you'll see. EVER!
1 Tom and Jerry
Tom and Jerry is an American animated series of short films created in 1940, by William Hanna and Joseph Barbera.
YES! SOMETHING THAT BEAT LIV AND MADDIE! HOORAY!
Okay seriously, Tom and Jerry are funny as heck, loved those cartoons as a kid. - KennyRulz244444
They're bitter rivals, but still both protagonists. You can't have one without the other.
This show is a classic! - RiverClanRocks
2 Adventure Time
Adventure Time is an American animated television series created by Pendleton Ward for Cartoon Network. The series follows the adventures of a boy named Finn (voiced by Jeremy Shada) and his best friend and adoptive brother Jake (voiced by John DiMaggio)—a dog with the magical power to change shape ...read more.
Love finn and jake very good people - assassinknight
Focuses largely on both Finn and Jake. - Garythesnail
3 Steven Universe
Steven Universe is an American animated television series created by Rebecca Sugar for Cartoon Network. The show's based around a young boy by the name of Steven Universe, who is a hybrid of a gem and a human. He lives with his gem friends, Garnet, Amethyst and Pearl.
4 Liv and Maddie
Liv and Maddie is a live-action Disney Channel sitcom that started on July 19, 2013, and ended on March 24, 2017. It is about two identical twin sisters named Olivia "Liv" Rooney and Madison "Maddie" Rooney (both portrayed by actress Dove Olivia Cameron; born in January 1996 as Chloe Celeste Hosterman) ...read more.
This list was literally made so you could put your favorite "shows" on here.
Please God help me! - KennyRulz244444
Liv is just as important to the plot as Maddie is. I love how they're best friends despite being completely different! That's why it's like The Fox and the Hound!
Teletubbies is a British pre-school children's television series created by Ragdoll Productions' Anne Wood CBE and Andrew Davenport, who wrote each of the show's 365 episodes .
That sun with the baby face still freaks me out - ShuhBanggg
Of the four Teletubbies, Po is my favorite of them by far. Go, Po, go!
Wow telling someone to grow up.
Ever heard of nostalgia?
The new Teletubbies is very different to the 90s.
1. The house indoors.
2. Noo-Noo is orange.
3. The babies called Tiddlytubbies.
4. Po has a helmet now when she rides her scooter!
5. Dipsy might be darker.
Rugrats is an American animated television series created by Arlene Klasky, Gábor Csupó and Paul Germain for Nickelodeon.
Similar to Teletubbies, there are four protagonists who are all babies. The difference? They aren't aliens.
Rugrats is better than Teletubbies by one billion miles.
At least it isn't creepy! - KennyRulz244444
"A baby's gotta do what a baby's gotta do! " -Tommy Pickles - ShuhBanggg
7 Looney Tunes
Looney Tunes is an American animated series of comedy short films produced by Warner Bros. from 1930 to 1969 during the golden age of American animation, alongside its sister series Merrie Melodies.
Like Tom and Jerry, it's a classic show from the good old days.
8 Totally Spies!
Totally Spies! is a French-Canadian animated spy comedy television series created by Vincent Chalvon-Demersay and David Michel and produced by Marathon Media Group and Image Entertainment Corporation.
9 Full House
Full House is an American sitcom created by Jeff Franklin for ABC. The show chronicles a widowed father, Danny Tanner, who enlists his best friend and brother-in-law to help raise his three daughters.
All the family are the protagonists.
10 Best Friends Whenever
Best Friends Whenever is an American multi-camera sitcom developed for Disney Channel, created by Jed Elinoff and Scott Thomas and executive produced by Jed Elinoff, Scott Thomas, and Michael B. Kaplan. The series stars Landry Bender as Cyd, Lauren Taylor as Shelby, Gus Kamp as Barry, Ricky Garcia as ...read more.
I like the fact that Cyd and Shelby can time travel. It's very interesting!
11 Phineas and Ferb
Phineas and Ferb is an American animated comedy-musical television series. Originally broadcast as a one-episode preview on August 17, 2007 and again previewed on September 28, 2007, the series officially premiered on February 1, 2008 and ended on June 12, 2015 on Disney Channel, and follows Phineas ...read more.
Another buddy show.
12 Winx Club
Winx Club is an Italian animated television series directed, created and produced by Iginio Straffi and his company Rainbow S.r.l.
Best show I've ever seen! Sailor Moon is the best too, and sometimes it's hard to choose which is bettter! Also, there are 5 main characters: Bloom, Stella, Flora, Musa, and Aisha. My favorite is either Stella or Flora. - BlueTopazIceVanilla
13 Drake & Josh
Drake & Josh is an American television sitcom created by Dan Schneider for Nickelodeon. The series follows the lives of two teenage boys with opposite personalities, Drake Parker (Drake Bell) and Josh Nichols (Josh Peck), who become stepbrothers. Both actors previously appeared in The Amanda Show along ...read more.
Even if you hate this show or any other Disney or Nick show on this list, you at LEAST have to admit: they are FAR better than the crap currently on Disney and Nick now.
I miss this show hey anyone remember the one when they made a sitcom about drake and josh in drake and josh lol - assassinknight
This is the best nick sitcom ever! No modern nick show can beat it! - nintendofan126
I love this sitcom! - SamuiNeko
14 Regular Show
Regular Show is an American animated television series created by J. G. Quintel for Cartoon Network that premiered on September 6, 2010. The series revolves around the lives of two friends, a blue jay named Mordecai and a raccoon named Rigby—both employed as groundskeepers at a local park.
It's hard to define which of the two is the "main" protagonist. - Garythesnail
5 Words... THIS SHOW should BE NUMBER 1
15 Teen Titans
Teen Titans is an American animated television series created by Glen Murakami, based on the DC Comics characters of the same name.
Not teen titans go! that show is crap but this show yes just yes - assassinknight
16 The Amazing World of Gumball
The Amazing World of Gumball is a British-Australian-German-American-Irish children's animated television series created by Ben Bocquelet for Cartoon Network.
love the fact that gumball and darwin depend on each other but their not brothers - assassinknight
Gumball and Darwin
17 We Bare Bears
An animated comedy show by Daniel Chong about three different species of bears - Grizzly, Panda and Ice bear (polar bear). Since they were little, they wanted to get adopted by owners separately. But then they missed each other too much, so they reunited again. Now as adults, they now live in a cave ...read more.
18 Gravity Falls
Gravity Falls is an American animated television series produced by Disney Television Animation that first aired on Disney Channel, and then on Disney XD from June 15, 2012 to February 15, 2016. The series follows the adventures of Dipper Pines and his twin sister Mabel in the fictional town of Gravity ...read more.
Catscratch is an American animated television series created by Doug TenNapel (also known for creating Earthworm Jim). It was aired on both Nickelodeon and Nicktoons on July 9, 2005. It is an adaptation of TenNapel's graphic novel, Gear, which is also the name of the cats' monster truck. The series ...read more.
I miss this show. I don't understand why it only got one season when shows like The Mighty B!, Breadwinners, Rabbids Invasion, Sanjay and Craig, and Fanboy and Chum Chum were given at least two or three seasons.
20 Family Guy
Family Guy is an American adult animated sitcom created by Seth MacFarlane for the Fox Broadcasting Company. The series centers on the Griffins, a family consisting of parents Peter (Idiotic Dad) and Lois (Nagging Wife), their children Meg (Socially Awkward Daughter) Chris (Idiotic Son), and Stewie ...read more.
21 That '70s Show
That '70s Show is an American television period sitcom that originally aired on Fox from August 23, 1998, to May 18, 2006. The series focused on the lives of a group of teenage friends living in the fictional suburban town of Point Place, Wisconsin, from May 17, 1976, to December 31, 1979.
22 The Grim Adventures of Billy & Mandy
The Grim Adventures of Billy & Mandy (also known as Billy & Mandy) is an American animated television series created by Maxwell Atoms for Cartoon Network, and is the 14th of the network's Cartoon Cartoons (albeit namely when it was part of Grim & Evil; the show is considered separate from Cartoon Cartoons ...read more.
23 Dragon Ball Z
Dragon Ball Z is a Japanese anime television series produced by Toei Animation. Dragon Ball Z follows the adventures of Goku who, along with the Z Warriors, defends the Earth against evil. The action adventures are entertaining and reinforce the concept of good versus evil. Dragon Ball Z teaches valuable ...read more.
F•R•I•E•N•D•S is an American television sitcom, created by David Crane and Marta Kauffman, which originally aired on NBC from September 22, 1994, to May 6, 2004, lasting ten seasons. It now airs on Nick at Nite. ...read more.
All 6 friends are main characters
25 The Simpsons
The Simpsons is an American animated sitcom created by Matt Groening that originally started on April 19, 1987 as shorts on The Tracey Ullman Show. It got its own series on December 17, 1989 and is still running as of 2018, making it the longest running animated sitcom. It is about a man named Homer ...read more.
26 The Fresh Prince of Bel-Air
The Fresh Prince of Bel-Air is an American sitcom that originally aired on NBC from September 10, 1990, to May 20, 1996.
If you ARE NOT a young kid and like mysteries and some fantasy stuff sort of and maybe some relationship things then Haven could be a good show for you. And note that I said COULD BE. - Anonymousxcxc
28 Teen Titans Go!
'Teen Titans Go!' is an American animated television series produced by Cartoon Network. The show follows a superhero group called the Teen Titans, and shows what happens when they go home and have silly adventures. This show is Cartoon Network's revival of the popular 2003-2006 American animated television ...read more.
29 The Wizards of Waverly Place
31 Buffy the Vampire Slayer
Buffy the Vampire Slayer is an American television series created by Joss Whedon under his production tag, Mutant Enemy Productions with later co-executive producers being Jane Espenson, David Fury, David Greenwalt, Doug Petrie, Marti Noxon, and David Solomon. The series premiered on March 10, 1997, ...read more.
32 Harvey Beaks
Harvey Beaks is an American animated television series created by C.H. Greenblatt for Nickelodeon. Originally announced to premiere on March 29, 2015, the series instead premiered on March 28, 2015 following the 2015 Kids' Choice Awards.
Clarence is an American animated television series created by Skyler Page for Cartoon Network. The series revolves around a young boy named Clarence and his two best friends Jeff and Sumo. Page, a former storyboard artist for Adventure Time and revisionist for Secret Mountain Fort Awesome, developed ...read more.
34 South Park
South Park is an American adult animated sitcom created by Trey Parker and Matt Stone for the Comedy Central television network. The show is about four boys, who are Stan Marsh, Kyle Broflovski, Eric Cartman, and Kenny McCormick, and their adventures in South Park, Colorado.
35 Game of Thrones
Game of Thrones is an American fantasy drama television series created by David Benioff and D. B. Weiss. It is an adaptation of A Song of Ice and Fire, George R. R. Martin's series of fantasy novels, the first of which is titled A Game of Thrones.
This haunting series follows the thrilling yet terrifying journeys of Sam and Dean Winchester, two brothers who face an increasingly sinister landscape as they hunt monsters. After losing their mother to a supernatural force, the brothers were raised by their father as soldiers who track mysterious ...read more.
Dean and Sam Winchester. - PeeledBanana
37 The Brady Bunch
This and the Partridge Family are two of the best ones in my opinion!
Such an underrated T.V. show! Although Mike and Carol could be harsh sometimes...
38 The Partridge Family
R.I.P David Cassidy.