Top 10 Best Genetic Testing Services

AncestryDNA AncestryDNA is the top choice for individuals primarily interested in ancestry and genealogy. It focuses on tracing ethnic origins and connecting users with relatives through its industry-leading DNA database of over 25 million samples.

When you submit a saliva sample, AncestryDNA analyzes your autosomal DNA and provides an ethnicity breakdown showing the regions your ancestors came from. Results are displayed in an interactive online interface with maps and percentage estimates.

A major advantage of AncestryDNA is its integration with historical records. Subscribers gain access to over 20 billion historical documents, including census data, immigration records, and more, allowing them to build detailed family trees. The platform also identifies DNA matches within its database and estimates relationships, such as second cousins.

Because of its massive user base and record archives, AncestryDNA is the most powerful option for genealogy. It significantly increases the chances of connecting with unknown relatives compared to other services.

The platform is very user-friendly, with results typically delivered within 6 to 8 weeks. Its family tree-building tools and DNA match features are straightforward, making it accessible even for beginners.

AncestryDNA's ethnicity estimates are known for their accuracy and granularity, improving over time as the company refines its reference data. However, it is important to note that AncestryDNA focuses strictly on ancestry. Health-related genetic insights are not included in the standard test.

For genealogy enthusiasts, this focus is not a drawback, as AncestryDNA excels in what it does best. If your goal is to trace your lineage, discover ancestors, and build a detailed family tree, AncestryDNA offers the most comprehensive platform for ancestry research. Visit Website

23andMe 23andMe is a well-rounded DNA testing service that provides detailed ancestry breakdowns, family DNA matching, and extensive health and trait reports, all from a single test.

After submitting a saliva sample, users receive an ethnicity estimate covering 2,750+ regions worldwide, offering a highly detailed view of ancestral origins. The service also highlights unique genetic insights, such as the percentage of Neanderthal DNA in a user's genome.

For those interested in family connections, 23andMe has a large database of around 14 million users worldwide (as of 2023) and offers a "Relatives" feature that connects users with genetic matches. The testing process is simple: spit in a tube, mail it back, and receive results in about 3 to 4 weeks. The platform's interface is intuitive, making it easy to understand results without a background in genetics.

What sets 23andMe apart is the breadth of insights provided from a single test. The Health + Ancestry kit includes genetic health risk assessments and carrier status reports for inherited conditions, such as cystic fibrosis and BRCA-related cancers. Some of these health reports are FDA-authorized, ensuring a high standard of accuracy.

Beyond medical insights, 23andMe provides reports on genetic traits, such as cilantro preference or sweet tooth tendencies, and wellness factors, like genetic influences on sleep or weight. Results come with clear explanations, making them accessible to all users.

For individuals interested in both ancestry and genetic health insights, 23andMe offers tremendous value. Its all-in-one approach makes it one of the most comprehensive DNA testing services available. Visit Website

MyHeritage DNA MyHeritage DNA is a popular ancestry-focused test known for its affordability and strong features for family history, particularly for those with roots outside the U.S. This test uses a simple cheek swab (instead of a saliva sample) and provides an ethnicity breakdown along with a list of DNA matches.

MyHeritage's DNA database, while smaller than AncestryDNA's, is still substantial, with approximately 6.5 million DNA profiles. It has a strong international presence, often yielding more matches in Europe, Africa, and other regions where MyHeritage has an extensive user base. The platform supports 42 languages, making it highly accessible for global users.

Users receive an ancestry composition report with percentage estimates for different ethnic regions and can view a map of ancestral origins. One of MyHeritage's standout features is its integration with a robust family tree builder, allowing users to create and import family trees. Additionally, the platform provides access to a database of 19 billion historical records for genealogical research.

Turnaround time for results is relatively quick, typically around 3 to 4 weeks.

A key advantage of MyHeritage is its affordability. The kit frequently goes on sale, sometimes dropping to around $50 during promotions, making it one of the most budget-friendly DNA tests available. Despite the lower cost, it offers a wealth of features.

The MyHeritage interface is user-friendly and includes some fun extras, such as photo enhancement tools that can animate or restore old family photos. For more advanced users, MyHeritage provides a chromosome browser, allowing a detailed view of which DNA segments are inherited from specific populations.

Another benefit is that MyHeritage allows raw DNA uploads from other services. This means users who have tested with AncestryDNA or 23andMe can upload their data to receive MyHeritage insights for free.

While MyHeritage's database is not as large as AncestryDNA's, its strong international focus makes it a great option for individuals with multinational family backgrounds or those looking to connect with relatives overseas. It offers an excellent balance of affordability and comprehensive genealogical tools. Visit Website

Living DNA Living DNA offers a unique two-in-one approach. It provides a deep dive into your ancestry, especially if you have British or European heritage, and includes a basic health and wellness analysis in one test.

For ancestry, Living DNA is known for its granular regional breakdowns. For example, if you have British ancestry, it can pinpoint percentages from specific regions within the UK, such as Cornwall or Yorkshire. In total, it covers over 150 regions worldwide, giving a detailed ethnicity report. Living DNA also traces your maternal and paternal haplogroups, your ancient family lines on your mother's and father's sides, which can reach back thousands of years. Their interactive migration maps show how your ancestors moved around the globe over the past 500 years.

The test uses a cheek swab that you mail back, with results ready in about six to eight weeks. On the health side, Living DNA's Wellbeing reports, included at no extra charge, analyze how your genes may affect your response to certain vitamins, foods, and exercises. This means you will get insights such as how you metabolize caffeine or whether you have genetic traits for endurance versus power in athletics, along with personalized diet and fitness suggestions.

The combination of detailed ancestry and actionable wellness tips makes Living DNA stand out. It is an especially great choice if you are interested in both your roots and some guidance for healthy living. The ancestry report has a rich historical context, including haplogroup information and migration narratives that bring your family history to life.

For users of African, European, or British descent, the level of regional detail is often more specific than what larger tests provide, since Living DNA was initially developed with a focus on UK and European genetics. On the wellness front, while it is not as extensive as a dedicated health test, it does provide useful pointers. Think of it as bonus content that can tell you if you might need more of certain vitamins or whether your genetics favor certain types of diets.

Another plus is that Living DNA has a strong privacy ethic. Data is not sold or shared without consent, and they offer free shipping for returning your sample. The platform itself is very visual and educational.

The trade-off is that Living DNA's database for relative matching is relatively small, so it is not the best choice if cousin-finding is your main goal. However, for deep regional ancestry insights plus some health and lifestyle guidance, Living DNA provides a highly engaging experience.

FamilyTreeDNA FamilyTreeDNA (FTDNA) is a long-standing company that caters to genealogy enthusiasts who want to dig deep into their ancestry. Unlike most other consumer DNA tests, FamilyTreeDNA offers specialized tests for your direct maternal line, called an mtDNA test, and direct paternal line, a Y-DNA test for males, in addition to the standard autosomal DNA test, called Family Finder.

This means that if you are curious about your father's father's father or your mother's maternal ancestors, FTDNA can trace those lines separately. This is great for verifying family tree research or uncovering ancient origins. The autosomal Family Finder test provides the usual ethnicity breakdown and relative matching. FTDNA's ethnicity estimates cover around 60 populations and can detect even small percentages, below 1%, of ancestry from different regions.

The platform also includes an interactive chromosome browser that lets you see the exact DNA segments you share with a match, which advanced users love. After a cheek swab and a wait of a few weeks, results can take anywhere from two to eight weeks, you will get access to a rich dashboard of tools.

The biggest draw of FamilyTreeDNA is its in-depth analysis of maternal and paternal heritage. For example, with a Y-DNA test, a male customer can uncover the migration path of his surname line and see if he shares a common ancestor with others of the same last name. The mtDNA test can similarly trace one's maternal lineage back to ancient times in Africa. These tests go far beyond the timeframe of typical ethnicity reports, often identifying one's haplogroup and deep ancestral origins.

FamilyTreeDNA's community is also a perk. Many users participate in group projects, such as surname projects or regional DNA projects, to collaboratively research their roots. While FTDNA's autosomal database for cousin matching is not as large as Ancestry's or 23andMe's, it does allow free DNA data uploads from other services, which means you can pull in matches from elsewhere.

The site's interface is a bit more utilitarian. It is packed with data and tools, which is great for power users but can feel complex to newcomers. However, if you are serious about genealogy and want tools like a chromosome browser, or you have specific questions that only Y-DNA or mtDNA can answer, FamilyTreeDNA is unmatched. It provides unique insights into your ancient ancestry and family lines that no other single company offers in one place.

Nebula Genomics Nebula Genomics is for those who want all the data their DNA has to offer. Unlike typical tests that sample a subset of your DNA, Nebula performs 30x whole genome sequencing, essentially decoding 100% of your DNA with high coverage.

This means you're not just getting snippets of genetic information. You're getting the whole picture, from ancestry insights to every health-related marker scientists know how to interpret (and even many they don't yet). The process is still consumer-friendly: you order a kit, provide a saliva sample (cheek swab), and mail it back. Because the sequencing is comprehensive, results take longer. It takes about 13 weeks for the full results to arrive.

When ready, Nebula provides a wealth of data and reports. You receive an ancestry analysis that includes identification of your maternal and paternal haplogroups, tracing deep ancestry on both sides.

For health and traits, Nebula currently offers reports on more than 27 health-related traits and behaviors. These range from traits like earwax type and freckling to wellness factors like alcohol flush reaction or exercise response. They also include some fun ones, like "genetic muscle composition," which has been linked to elite athletes. However, the real power lies in the ability to dig into the raw genome data via Nebula's interface or download it for use elsewhere.

The depth of information is Nebula's hallmark. Because it sequences every gene, you are essentially future-proofing your DNA test. New genetic discoveries can be applied to your raw data without needing to test again. Nebula even provides a curated research library where each week, you can see the latest scientific studies and how your genome relates to them.

Privacy is another focus. Nebula was co-founded by genomics pioneer George Church, and they have strong privacy measures, including an option to remain anonymous and keep your data in an encrypted vault. That said, Nebula's comprehensive approach comes with a higher price tag, often a few hundred dollars, and a subscription model for ongoing reports.

The data is also quite complex. The average user might find some of the raw genome exploration tools a bit technical. Unlike some clinical tests, there is no genetic counseling provided. Instead, Nebula appeals to the DNA power-user or health data enthusiast who wants maximum information and does not mind wading through it.

In summary, Nebula Genomics offers highly detailed results by sequencing your entire genome. It is the best choice if you want to invest in a deep genetic profile that you, and even your doctor or researcher friends, can explore to the fullest extent.

SelfDecode SelfDecode takes a unique approach by focusing on personalized health, wellness, and lifestyle insights powered by DNA.

You can use SelfDecode in two ways. If you've already tested with another service, such as Ancestry or 23andMe, you can upload your raw DNA data and receive instant reports. Alternatively, you can order SelfDecode's own DNA testing kit, which uses a cheek swab and analyzes an impressive 83 million genetic variants. This is a much broader analysis than typical DNA microarrays.

SelfDecode operates on a subscription-based model, providing access to over 350 reports covering a wide range of topics. These include health areas such as gut health, cardiovascular health, hormone balance, and mental health, along with diet and nutrition reports, fitness traits, personality insights, and even supplement recommendations.

Instead of simply stating, "You have gene X, which is associated with Y," SelfDecode provides actionable health recommendations. For example, if your genetics suggest a higher risk of vitamin D deficiency, the report will outline steps such as dietary changes or lifestyle adjustments. The reports are detailed but written in plain English, often including helpful graphics.

Another key feature is its holistic approach. SelfDecode asks users to fill out a health and lifestyle questionnaire and integrates that information with genetic data to refine its recommendations.

For users interested in biohacking or optimizing wellness, this service is a goldmine. It even offers specialized "biohacker" reports. Additionally, SelfDecode covers niche topics such as mental well-being, stress response, and cognitive function genetics, which many other services do not.

SelfDecode is a fully digital service, delivering everything via an online dashboard. There are no printed reports, and it operates on a membership model, either annual or lifetime, granting users ongoing access to new and updated reports.

If you're looking for a service that provides medical diagnostic results, this isn't it. You won't receive a doctor's note diagnosing a disease. Instead, SelfDecode is about self-guided improvement, using DNA insights as one piece of a larger health puzzle. It is ideal for health-conscious individuals who want ongoing insights and personalized recommendations to optimize their lifestyle.

tellmeGen tellmeGen is a Spain-based company that has gained international attention by offering an extremely comprehensive DNA test for consumers. Their Advanced DNA test kit analyzes over 750,000 genetic markers from a saliva sample, covering a broad spectrum of reports.

These include health predispositions (genetic risk for diseases), carrier status for inherited conditions, pharmacogenetics (how your body might respond to certain medications), wellness traits (such as vitamin and food metabolism), and a variety of personal traits (including eye color, hair traits, and behavioral tendencies). In total, tellmeGen provides over 400 reports across these categories, making it one of the most feature-rich DNA test kits available.

The kit also includes basic ancestry information. You receive an ethnicity breakdown and can view DNA matches through their "DNA Family" matching service. However, their ancestry database is smaller than those of major U.S. companies. Notably, tellmeGen even offers testing for children and infants (with proper parental consent), allowing parents to gain genetic insights from an early age.

Results are delivered via an online portal, where reports are neatly organized by category (Health, Traits, Wellness, Ancestry, etc.). These reports are continually updated as new genetic research emerges.

One of tellmeGen's biggest advantages is that all reports and future updates are included in the initial price. There are no subscriptions or add-ons required. The kit is often priced between $100 and $150, with bundle deals available for families. This means that if a new genetic trait is discovered next year, tellmeGen will update your dashboard with that information at no additional cost.

The health reports are quite detailed and cover a wide range of conditions. However, as with any direct-to-consumer test, these provide probabilistic insights rather than medical diagnoses. They also offer an optional consultation service with a doctor (available for an extra fee) for those who want professional guidance on their results.

In terms of user experience, tellmeGen's platform is available in English and is designed to be user-friendly, with clear explanations and graphs for each trait. Another advantage is that they comply with strict European privacy laws, which can be reassuring for those concerned about data security.

While the ancestry component is a useful addition, it does not match the depth of AncestryDNA's database. For this reason, tellmeGen is best suited for individuals primarily interested in health and trait analysis, with only a general curiosity about ancestry. As one of the most complete all-in-one DNA test kits on the market, it offers great value for those looking for a wide array of genetic insights without needing multiple tests.

MyToolbox Genomics MyToolbox Genomics (often called Toolbox Genomics) is a genetic testing service focused on turning DNA insights into actionable wellness plans. It stands out by not just providing genetic data but also offering personalized diet, fitness, and lifestyle advice based on your results.

The DNA test analyzes key genetic markers related to health and wellness, covering about 16 different areas. These include nutrition, exercise, metabolism, and even virus susceptibility, which refers to how your body might handle certain infections.

You can also opt to bundle an epigenetics test, which measures markers on your DNA that indicate your "biological age" and how your environment and lifestyle have affected your genes. This is a separate add-on that requires a blood sample. A typical MyToolbox Genomics package includes an overview of your genetic predispositions. For example, it may indicate whether you need more of certain vitamins or if you have a higher risk for high blood pressure with an improper diet. The key feature is that the service translates these findings into customized meal plans, workout suggestions, and health tips tailored to your genetic profile.

The process involves ordering the kit, registering it with their mobile app, collecting a saliva sample, and sending it back. Results are available in about 3-4 weeks and can be accessed through the Toolbox Genomics app or website.

The main selling point of MyToolbox Genomics is its focus on actionable insights. Instead of simply identifying a gene associated with lactose intolerance, the platform offers dietary adjustments and alternative nutrition strategies. If your genes suggest you respond better to endurance training than strength training, the system may generate a workout plan emphasizing cardio.

It's like having a genetic coach. The reports are straightforward, and the app is designed for everyday users, featuring charts and recommendations that are easy to follow. Another unique aspect is that Toolbox Genomics continuously evolves, updating its app with new features, such as tracking how well you follow the suggested plan and offering adjustments.

The service also stands out for its focus on environmental factors, offering epigenetic testing, which few consumer-focused companies provide. In terms of scope, Toolbox Genomics does not cover ancestry at all. It is purely about health and wellness traits. Think of it as a DNA-based lifestyle optimization tool.

It is particularly appealing if you want to fine-tune elements like your diet, vitamins, exercise routine, sleep, and stress management based on genetic tendencies. While the price is on the higher side (around $199 for the DNA test, with additional costs for epigenetics), users who see it as an investment in personalized wellness often find it worthwhile.

In short, MyToolbox Genomics is an excellent choice for those who want to translate genetic insights into day-to-day health and wellness strategies.

LetsGetChecked (myGeneticScreen) LetsGetChecked is well known for its at-home health tests (like blood tests), and now it has expanded into DNA testing for serious health risks with a service called myGeneticScreen.

Launched in 2024, myGeneticScreen is a genetic test designed to identify hereditary risks for certain cancers and heart conditions. The test focuses on the CDC's Tier 1 genetic conditions, which include three conditions that health authorities emphasize as especially important to know about: Hereditary Breast and Ovarian Cancer syndrome (mutations in BRCA1/BRCA2 genes), Lynch syndrome (a cause of colon and other cancers), and Familial Hypercholesterolemia (which causes very high cholesterol).

The idea is that these conditions have proven prevention or treatment strategies if caught early. The process is medical-grade yet still convenient. You order the kit, provide a saliva sample at home, and send it back. Importantly, a physician is involved, either your own or one through LetsGetChecked, to review and order the test. Pre- and post-test genetic counseling is included.

In about 2-3 weeks, you receive a secure online report detailing any genetic mutations found in the 11 genes that are analyzed. These genes are tied to the Tier 1 conditions. If something significant is detected, a genetic counselor will explain what it means and discuss next steps, such as seeing a specialist or undergoing enhanced screening.

LetsGetChecked's genetic service is unique in that it balances direct-to-consumer convenience with clinical-level testing. Traditionally, this kind of test would only be available through a doctor's office, but LetsGetChecked makes it accessible from home while still involving doctors and genetic counselors.

That means the results are actionable in a medical sense. You can take them to your physician and make informed decisions about cancer screening or preventive measures. The actionability and support are key. The included genetic counseling ensures you're not left alone to interpret a complex result, and they guide you on what to do next. Privacy and accuracy are also high priorities. The testing is done in a CLIA-certified lab, adhering to the same standards as hospital labs.

It's worth noting that this test is narrowly focused. It does not provide ancestry information, trait reports, or minor health trait insights. It is specifically designed for identifying serious hereditary risks. For many consumers, this is actually a benefit, as it avoids information overload and focuses on life-saving insights.

Through acquisitions, such as LetsGetChecked acquiring full genome sequencing capabilities from Veritas Genetics, the company is positioning itself to offer even more genetic tests in the future. This may include whole genome sequencing with both health and ancestry reports. However, as of 2025, myGeneticScreen remains their flagship DNA product.

If your primary interest is health risk screening in a physician-supported model rather than exploring ancestry or general traits, myGeneticScreen is a top choice. LetsGetChecked provides an easy on-ramp to clinical genetic testing, making preventive genetic health screening accessible from home while keeping you connected to professional medical guidance.