Top Ten Best Items In The Binding of Isaac: Rebirth
The Top Ten
1 Brimstone
Easily the best. Amazing synergies, excels at clearing rooms and destroying bosses, and has unlimited range.
The damage to every enemy is crazy
2 Mom's Knife
A single damage up with this item allows for rapid destruction when using it as melee.
3 Holy Mantle
4 Godhead
Hard to unlock but is worth it
5 Polyphemus
6 Sacred Heart
7 Stop Watch
Not anymore it isn't.
8 20/20
9 Magic Mushroom
Great to get at the start of a game
10 Cricket's Head
The Contenders
11 The D6
12 The Book of Belial
The increased chance of devil rooms is great
13 Epic Fetus
14 The Pinking Shears
15 Abaddon
16 Death's Touch
17 The Wafer
18 Dark Bum
19 Mutant Spider
20 Ceremonial Robes
21 Ipecac
22 The Pact
23 The Mark
24 The Small Rock
25 Money = Power
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