Worst Items in the Binding of Isaac

Trash. Just a little knockback and no damage. The only time it could ever be useful would be against Fistula or Envy, both of which are easy.

Why would you ever use this!? Normally, you start a run as a particular character because you want to finish it with them and unlock something!

Trying to progress as a good character and using Clicker once you have good items is incredibly unreliable. The chance of Clicker even appearing is (thankfully) low, and the chance of transforming into the character you want is also low. Incredibly flawed, and it is a huge mistake. Even Butter Bean is better.

The Clicker is by far one of the, if not the, worst items in the game. When used, it switches you to a different character. But that is not the worst part! Not only does it eliminate your chances of getting any completion marks, but upon each use, the Clicker removes your oldest passive item. That is just terrible.

Butter Bean may not do much, but at least it does not remove any of your passive items!

The worst familiar in the whole game. First of all, it flies around on the opposite side of the room, mirroring your moves, and firing towards the center of the room. Your shots will rarely ever hit anything. Plus, it has very short range, damage, and shot speed, with no special effects that will help in any possible way.

Give it the ability to fire the exact same tears as Isaac at the same rate like Incubus does, but I guess we're stuck with this garbage for now...

Abel is just terrible. As said previously, nothing can be hit, and there are no perks to it. Plus, in Greed mode, it has a chance to spawn, reducing the quality of the run by not giving a better item.

An item that gives invincibility unlimited times sounds good, but Breath of Life proves that something that would sound good can actually be awful. It takes about 6 seconds to actually activate the invincibility frames, and it lasts less than a second. After that, you have to wait another 6 seconds until it can even start the 6-second charge again. If you overhold the charge button, you will take damage.

It would not be of any use in a fight since you will need to hold the charge button, which would force you to focus on its charge time while the enemy can shoot at you all it wants. Your shots probably won't land many hits since you won't even be focusing on the fight.

Rerolls all enemies in the current room. Seems like it could be useful, but then you realize that it rerolls them into almost any enemy, even ones only found several chapters later.

You might think it could come in handy later, but it's still too unpredictable. Eventually, mainly bosses and mid-bosses spawn, which can't be rerolled. Even in situations where it could be useful, it still doesn't do too much and will make barely any impact on the game.

Having a random tear effect for the rest of the room sounds good, and giving you a chance to permanently raise a random stat is also nice. Dataminer absolutely ruins it. It takes 4 rooms to recharge, so for 3 out of 4 rooms, you won't even have any special effects. The enemies also have their sprites rotated, making them a nightmare to hit, and it gets super confusing.

The worst part is that it has a chance to lower your stats. It's not even like it has a very small chance of happening. It has a 50/50 chance to raise or lower stats. While it might seem like it would help balance it out, it's not uncommon that you'll end up with a very weak damage stat, while your range is high enough that it couldn't possibly be more useless. It's not worth the risk because it has practically no benefits that could be useful in the long term.

Having a slot machine to take with you sounds okay, being able to generate hearts during a tough fight, but it is actually a pretty damn stupid idea. Whenever you lose at the portable slot (which is highly likely), you will stop firing for a few seconds, which could mean the difference between loss and victory in a difficult fight.

Unlike a regular slot, you can't just blow it up. It will never drop a dollar either. If that wasn't enough, it will shred through your coins, often giving you nothing more than a bomb or key.

Only take this item if you have Tiny Planet or Ludovico Technique, both of which are also bad in their own right!

Bob's Brain can sometimes be helpful to destroy a bunch of enemies. However, using the item is basically SUICIDE. If you play with characters like The Lost, Azazel, The Forgotten, or others, you have limited hearts and you might fire too close to yourself by accident. Oh, actually, it's almost certain.

You probably will forget about it, and when it spawns, you will die or lose hearts.

Have fun blowing yourself up in the face every now and then!

Glass Cannon takes away all your hearts except for half of one. You can then fire powerful shots every few seconds. Given that it means a single hit will kill you (unless you have Holy Mantle), it would have to be pretty damn powerful to make up for it. You would be wrong.

It is nothing special, and even if it were that powerful, it wouldn't be worth it since it means you are forced not to take damage. When you finally get a few soul hearts for safety, using it again will take them all away!

This item reduces your main health to 1. This is not much of a problem if you are playing as a character that can have red hearts and you have a bunch of soul hearts in your health gauge. Sure, this item does contribute to the "Guppy!" transformation.

However, if you do not have any soul hearts in your health gauge or play as a character that operates solely on soul hearts, then your run is compromised the moment you pick this up, especially since the 4th chapter and beyond has every enemy deal a full heart of damage (unless you have the Wafer).

Thanks for the "hints." The only use it had was to discover Easter egg seeds, which are now all just on the wiki.

That is not even an item but rather a card pickup. That said, it does not have an actual effect upon use.

This item needs a buff. They should make it so that the player can still fire tears while controlling the floating Ludovico tear. That way, the player can alternate between actively shooting tears and targeting enemies from afar while standing behind rocks.

Ludovico Technique is just BORING to use. You control a single floating tear, and it moves soooooo slooowww. But at least the damage ticking rate depends on the Tears stat, so a high Tears stat can mean high DPS. But if your Shot Speed is abysmal, then your run is ruined.

Being able to bring enemies towards your tears is really good!... if you happen to have Ludovico Technique, Dr. Fetus, or Epic Fetus. Otherwise, it is suicide. Certain enemies will be flung towards you at rapid speeds, and overall, it will do barely any more damage.

It will kill you, and the only reason that this isn't higher up is because it has a few good synergies, and they all have much better synergies that will be much more useful.

Picking up Experimental Treatment can either be good or bad. In the best-case scenario, you will get a decent Damage Up and Tears Up, and only a mild Speed Down, Luck Down, or Range Down. In the worst-case scenario, your Damage and Tears stats would go down like the Titanic while only your Range stat, which is only a dump stat at best, flies up to the roof.

Swinging weapons, in particular, are crippled by a high Range stat, as it does not make the swing bigger but instead displaces the swing hitbox itself by a large amount, making it harder to hit anything.

It rerolls all your items. Now if you have like 20 Lunches and they get rerolled into Godhead, that will get rerolled every floor that passes.

All of your passive items reroll every floor. Essentially a budget Tainted Eden in a single item.

Epic Fetus? More like CRAPpic Fetus! This item takes too long to damage any enemies in the room!

Not to mention all of the synergies it deletes, and the fact that it STILL exists in the Secret Room item pool!

At Quality 4, no less! This item deserves Quality 3 at most.

1. When you release the reticle, the air strike takes forever to come down.
2. This item overrides pretty much the whole database of items in the game, other than bomb upgrades and tear multipliers, like 20/20, the Inner Eye, etc.
3. Why is this item in the Secret Room item pool?!

At least it contributes to the "Guppy!" transformation.