Top 10 Female Anime Characters with Breasts So Big They Practically Have Macromastia

Macromastia, or breast hypertrophy, is a condition where a women's breasts grow to massive size. It was first described in 1648 and some doctors believe it occurs when a woman's breasts become big enough to account for 3% of their body weight. One of the most famous incidents of macromastia is that of Punky Brewster actress Soleil Moon Frye where her breasts grew like crazy in her mid-teens. Many women and girls who develop macromastia aren't exactly happy with what mother nature gave them. But in the world of anime, it's a very different story.

While drawing anime characters can be difficult and take time to practice, breasts are one of the easiest parts to draw. In fact, probably the hardest part of drawing breasts is practicing self-control. And because anime isn't just for children, it's surprisingly easy to go overboard when drawing these parts. And that has resulted in many female anime characters with macromastia-esque breasts. So here are ten such anime characters to start with and I'm counting on the community to add more.
The Top Ten
1 Komoe Harumachi - Eiken

While there are numerous overly busty gals in Eiken, Komoe Harumachi easily stands above the rest. What makes her noteworthy is that she not only has the largest breasts in the anime and 2nd largest in the manga, she's also the youngest member of the Eiken club. It's amazing how she's able to do anything when her breasts are practically as big as her whole body.

2 Milky - Interspecies Reviewers

This is probably one of the most controversial anime ever because it involves a quartet of men as they visit various brothels designed for whatever sexual fetish men desire. Two of the most well-known girls are Milky and Ginny, female minotaurs with massive breasts who work at a brothel called The Dairy Farm. If by some chance this anime gets a second season, I would love to see more of these girls.

3 Cattleya - Queen’s Blade

When it comes to sexual innuendo, Queen's Blade pulls no punches. This is made clear in the first episode when Leina and Melona cross paths. One of the most notable female characters is Cattleya, who has the largest breasts of the series. Despite her appearance, Cattleya is surprisingly strong and can wield a giant sword very easily. In fact, her breasts are so big, her son Lana could probably fit inside one.

4 Tomo Yamanobe - Seikon No Qwaser

Also known as Qwaser of Stigmata, this show has a pretty bonkers premises that I'd rather not discuss. What blows my mind about this series is that it has a Canadian Home Video Rating of only 14+, meaning minors as young as 14 years old in Canada can either buy or rent it. This is definitely one anime you shouldn't let your parents catch you watching regardless of the age rating. While Tomo might not have the largest breasts in the series, her role as a main character definitely sets the tone for the anime.

5 Ilulu - Miss Kobayashi's Dragon Maid

I thought Quetzalcoatl's human-form had massive breasts. But when Season 2 debuted, Ilulu easily usurps her crown as the bustiest gal in the series. In fact, there was a bit of controversy surrounding her character when the second season was announced. Mainly because how her massive chests contrasts with her small stature.

6 Shizuka Marikawa - Highschool of the Dead

Highschool of the Dead is what some people call "The Walking Dead" if it was an anime. A bunch of Japanese highschool students and the school's nurse experience a zombie outbreak and must band together in order to survive. You can probably tell that Shizuka is the school's nurse. Even though it's part horror, there's usually a heavy dose of sexual innuendo. In one chapter of the manga where the group takes shelter in a mall, they hide their weapons in a bra bin. Classic. Despite the premise, this was actually pretty solid. It was a real shame when one of the creators, Daisuke Sato, passed away on March 22, 2017 from Heart Disease. While it can still technically continue, it probably won't follow what Daisuke had in mind.

7 Meiko Shiraki - Prison School

As the second in-command of the Underground Student Council at Hachimitsu Academy, Meiko is also the strongest student and proficient in martial arts. Unlike most anime girls who have macromastia purely for eye candy, Meiko's huge breasts are probably what drove her to become who she is today because of how she was bullied over them. Two recurring running gags are how she has wardrobe malfunctions and how she sweats up a monsoon when working out or in a state of fear.

8 Mizuki Tachibana - Gravion

Gravion is one of the earliest ecchi animes, premiering in 2002 and getting a sequel in 2004. One of the more prominent characters is Mizuki Tachibana, the only female adult member of Earthgertz and it definitely shows. In fact, I once saw an ad in a magazine for this anime that boasted "Gravity Defying Breasts" as part of it. Here's a fun fact; in the "Angel Blade Punish" anime, there's a character named Hazuki Tachibana who looks exactly like Mizuki. I guess changing one part of the name was enough to avoid getting in copyright related trouble.

9 Aki Nijou -Maken-Ki!

Maken-Ki! is the story about how a male student is enrolled in a co-ed school that used to be all female. One of the most notable members of the faculty is the nurse, Aki Nijou. In a flashback in one episode, her breasts started to really develop when she was only 12-years old. Of course, her teenage years have got nothing on how hot she is now.

Super sexy I love it

10 Akeno Himejima - High School DxD
The Contenders
11 Nami - One Piece Nami is a fictional character in the One Piece franchise created by Eiichiro Oda. She is based on Ann and Silk, two characters from Oda's previous manga Romance Dawn.
12 Murasaki - Senran Kagura: Shinovi Master

Ever since the series made its debut on the 3DS, girls with large breasts have basically been Senran Kagura's trademark, mainly because series creator Kenichiro Takagi thought of breasts in 30 seconds when he asked himself what people would want to see in 3D. In the first installment, it was difficult to determine which gal had the largest breasts. When Senran Kagura: Shinovi Versus was released, Murasaki's 105cm bust put the debate to bed. To date, she has the largest breasts in the series.

13 Tsunade - Naruto Tsunade is a fictional character from the manga and anime franchise Naruto, created by Masashi Kishimoto.
14 Quetzalcoatl - Kobayashi-san Chi no Maid Dragon

I love her boob

15 Hinata Hyuga - Naruto Hinata Hyuga is a fictional character in the anime and manga franchise Naruto, created by Masashi Kishimoto.
16 Centorea Shianus - Monster Musume
17 Lady J - Valkyrie Drive: Mermaid
18 Nene Fujinoki - Hajimete no Gal
19 Orihime Inoue - Bleach Orihime Inoue is a fictional character in the Bleach manga series and its adaptations created by Tite Kubo.

I'll make a strong statement and say that the author has never seen real boobs in his whole life

20 Erza Scarlet - Fairy Tale Erza Scarlet is an S-Class Mage from the infamous magic guild Fairy Tail. Erza starts off as a lone wolf and stays loyal to following the rules. As the story develops Erza changes into loving mage strong and independent. As her terrible past haunts her she ignores her Nakama's calls that they want help. more.
21 Hotaru Shidare - Dagashi Kashi
22 Rangiku Matsumoto - Bleach Rangiku Matsumoto is a fictional character in the Bleach manga series and its adaptations created by Tite Kubo.

I don't know why I didn't add her when making this list. When it comes to women with macromastia from Bleach, this gal is usually the first one that comes to mind.

Big boobs love it

23 Ayana Hizuki - Kagaku na Yatsura
24 Boa Hancock - One Piece Hancock has a well proportioned figure compared to the abnormal and huge appearance of her sisters. She is a very tall, slender woman with long black hair that extends past her waist with locks of hair that frame her face down to her chin, pale skin, large breasts, a high forehead, and dark brown (dark blue in the pre-time skip anime then changed into black after the time-skip) eyes that have long, voluminous lashes. Like most of the females in the series, she has a narrow waist. more.
25 Hotaru Ichijo - Non Non Biyori
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