1 Homer Simpson
Homer Jay Simpson is the protagonist of the American animated television series The Simpsons as the patriarch of the eponymous family.
2 Peter Griffin
Peter Griffin is the main protagonist and titular character of the American animated sitcom Family Guy.
3 Rainbow Dash
Rainbow Dash is a female Pegasus pony from the popular 2010 kid's show My Little Pony: Friendship is Magic. She represents the element of loyalty is one of most well known characters of the show.
She may be a little mean sometimes but she still does what is best for her friends .
I would totally annoy this twat any day! - nintendofan126
I love her she is super speedy with the power of rainbow dash
Yay! Let's grab guns and shoot her - TwilightKitsune
Rarity is a female Unicorn pony from the 2010 Animated Television Series My Little Pony:Friendship is Magic. She is the element of Generosity and her main passion is fashion.
I don't want to annoy her because I love her
5 Patrick Star
Patrick Star is a fictional character in the American animated television series SpongeBob SquarePants. He is voiced by actor Bill Fagerbakke, who also voices numerous other characters on the show . Created and designed by marine biologist and cartoonist Stephen Hillenburg, the series creator, Patrick ...read more.
6 Spongebob Squarepants
SpongeBob SquarePants is a fictional character and the titular character and protagonist of the American animated television series of the same name.
That'll be a challenge. - SamuiNeko
7 Squidward Tentacles
Squidward Tentacles is a fictional character voiced by actor Rodger Bumpass in the American animated television series SpongeBob SquarePants.
Squidward: (Playing his clarinet)
Princess Kiana: Booo!
Squidward: Go away! Can't you idiots take a hint!?
Princess Kiana: lol No. - PrincessKiana
SpongeBob and Patrick are pros at annoying Squidward. - Catacorn
8 Eric Cartman
Eric Theodore Cartman is one of the main characters in the animated television series South Park, created by Matt Stone and Trey Parker, and voiced by Trey Parker.
I'm pretty sure I wouldn't want to anger Cartman - GamerBoy
Don't anger Cartman, he might just cuss at you and beat you up!
Sheldon James Plankton, or simply Plankton, is a character in the Nickelodeon animated television series SpongeBob SquarePants.
10 Diamond Tiara
12 George Pig
Waha! Aaa! - Officialpen
13 Peppa Pig
I would so want to annoy that annoying hog any day!
14 Daffy Duck
Daffy Duck is an animated cartoon character produced by Warner Bros. Styled as an anthropomorphic black duck, the character has appeared in cartoon series such as Looney Tunes and Merrie Melodies, where he usually has been depicted as the best friend and occasional arch-rival of Bugs Bunny.
After watching Duck Amuck, it was just the most tempting thing ever. - PositronWildhawk
17 Ed - The Lion King
Simba is a fictional character who appears in Disney's The Lion King franchise. Introduced in Walt Disney Animation's 32nd animated feature film The Lion King (1994), the character subsequently appears in its sequels The Lion King II: Simba's Pride (1998) and The Lion King 1½ (2004).