1 Homer Simpson
Homer Jay Simpson is the protagonist of the American animated television series The Simpsons as the patriarch of the eponymous family.
2 Peter Griffin
Peter Griffin is the main protagonist and titular character of the American animated sitcom Family Guy.
3 Rainbow Dash
Rainbow Dash is a female Pegasus pony from the popular 2010 kid's show My Little Pony: Friendship is Magic. She represents the element of loyalty and is one of 6 mane characters on the show. ...read more.
I would totally annoy this twat any day! - nintendofan126
I love her she is super speedy with the power of rainbow dash
Yay! Let's grab guns and shoot her - TwilightKitsune
Rarity is a female Unicorn pony from the 2010 Animated Television Series My Little Pony:Friendship is Magic. She is the element of Generosity and her main passion is fashion.
I don't want to annoy her because I love her
5 Patrick Star
Patrick Star is a fictional character in the American animated television series SpongeBob SquarePants. He is voiced by actor Bill Fagerbakke, who also voices numerous other characters on the show . Created and designed by marine biologist and cartoonist Stephen Hillenburg, the series creator, Patrick ...read more.
6 Spongebob Squarepants
SpongeBob SquarePants is a fictional character and the titular character and protagonist of the American animated television series of the same name.
That'll be a challenge. - SamuiNeko
7 Squidward Tentacles
Squidward Tentacles is a fictional character voiced by actor Rodger Bumpass in the American animated television series SpongeBob SquarePants.
SpongeBob and Patrick are pros at annoying Squidward. - Catacorn
8 Eric Cartman
Eric Theodore Cartman is one of the main characters in the animated television series South Park, created by Matt Stone and Trey Parker, and voiced by Trey Parker.
I'm pretty sure I wouldn't want to anger Cartman - GamerBoy
Don't anger Cartman, he might just cuss at you and beat you up!
I wouldn't piss him off actually. Remember what happened to Scott Tenorman?
Sheldon James Plankton, or simply Plankton, is a character in the Nickelodeon animated television series SpongeBob SquarePants.
10 Diamond Tiara
12 George Pig
Waha! Aaa! - Officialpen
13 Peppa Pig
I would so want to annoy that annoying hog any day!
14 Daffy Duck
Daffy Duck is an animated cartoon character produced by Warner Bros. Styled as an anthropomorphic black duck, the character has appeared in cartoon series such as Looney Tunes and Merrie Melodies, where he usually has been depicted as the best friend and occasional arch-rival of Bugs Bunny.
After watching Duck Amuck, it was just the most tempting thing ever. - PositronWildhawk
17 Ed - The Lion King
Simba is a fictional character who appears in Disney's The Lion King franchise. Introduced in Walt Disney Animation's 32nd animated feature film The Lion King (1994), the character subsequently appears in its sequels The Lion King II: Simba's Pride (1998) and The Lion King 1½ (2004).
22 Dora the Explorer
Dora is the main protagonist in the show "Dora the Explorer" her main occupation is exploring with her monkey friend Boots .
23 Sid the Science Kid
24 Steven Universe
25 Mr. Garrison
Herbert Garrison is a recurring character in the American animated television series South Park. He is voiced by Trey Parker.
26 Cat In the Hat
27 Dora - Dora The Explorer
28 Morton Koopa Jr.
If you enter the Mushroom Kingdom in the Super Mario Bros 3 Super Show, you can annoy Loudmouth as long as you want, as long as you have lots of stars and fire flowers.
29 Lupo the Butcher
30 Spanky Ham
31 Princess Clara
Starscream is a fictional character in the Transformers franchise. He is one of the most frequently occurring characters in the Transformers fictional work, appearing in almost all versions of the story.