1 The Simpsons
The Simpsons is an American animated sitcom created by Matt Groening that originally started on April 19, 1987 as shorts on The Tracey Ullman Show. It got its own series on December 17, 1989 and is still running as of 2019, making it the longest running animated sitcom. It is about a man named Homer ...read more.
There have been quite a few cartoons inspired by the Simpsons, including Family Guy. The Simpsons have been an important part of Cartoons around the planet. - EpicJake
While it's best years are behind them there's denying The Simpsons had a huge influence in Animation. - egnomac
2 Mighty Mouse: The New Adventures
Created by Ralp Bakshi who pioneered adult cartoons and started the creator driven animation revolution of the 1990's, was the launching pad for animators and cartoonists including John Kricfalusi the creator of Ren & Stimpy. - egnomac
3 Dragon Ball Z
Dragon Ball Z is a Japanese anime television series produced by Toei Animation. Dragon Ball Z follows the adventures of Goku who, along with the Z Warriors, defends the Earth against evil. The action adventures are entertaining and reinforce the concept of good versus evil. Dragon Ball Z teaches valuable ...read more.
Wither you like it or not there's no denying that anime had a huge influence on American cartoons Dragon Ball Z was one of them, without anime we never would have cartoons like Samurai Jack, The Power Puff Girls, Teen Titans, Avatar The Last Airbender, Xiaolin Showdown the list goes on. - egnomac
4 Avatar: The Last Airbender
Avatar: The Last Airbender is an American animated television series that aired for three seasons on Nickelodeon from 2005 to 2008. Avatar: The Last Airbender is set in an Asiatic-like world in which some people are able to manipulate the classical elements by use of psychokinetic variants of Chinese ...read more.
Avatar was a huge game changer for Nickelodeon heavily inspired by anime Avatar The Last Airbender follows a young air bender and his friends on a quest to become a fully realised Avatar and restore balance to the world. - egnomac
5 The Flintstones
The Flintstones is the first animated prime-time American television series. It was broadcast from September 30, 1960 to April 1, 1966 on ABC.
The first cartoon made specifically for prime time which led the way for The Simpsons and Family Guy. - egnomac
This has got to be one of the best cartoons in the world. Good job Hanna-Barbera. - EpicJake
Pokémon, abbreviated from the Japanese title of Pocket Monsters and currently advertised in English as Pokémon: The Series, is a Japanese anime television series, which has been adapted for the international television markets.
7 Looney Tunes
Looney Tunes is an American animated series of comedy short films produced by Warner Bros. from 1930 to 1969 during the golden age of American animation, alongside its sister series Merrie Melodies.
Without Looney Tunes we wouldn't have Tom and Jerry. Looney Tunes is a classic. - EpicJake
Many cartoons incorporated references,quotes,phrases,soundtracks,ideas etc that originated from the looney tunes, such as spongebob, the simpsons, fairly oddparents and tom and jerry, just to name a few. It truly did define classic cartoon comedy with some of its greatness rubbed onto newer cartoons
8 South Park
South Park is an American adult animated sitcom created by Trey Parker and Matt Stone for the Comedy Central television network. The show is about four boys, who are Stan Marsh, Kyle Broflovski, Eric Cartman, and Kenny McCormick, and their adventures in South Park, Colorado.
9 Tom and Jerry
Tom and Jerry is an American animated series of comedy short films created in 1940 by William Hanna and Joseph Barbera. Best known for its 161 theatrical short films by Metro-Goldwyn-Mayer, the series centers on a rivalry between the title characters Tom, a cat, and Jerry, a mouse. Many shorts also ...read more.
10 The Ren & Stimpy Show
The Ren & Stimpy Show, often simply referred to as Ren & Stimpy, is an American animated television series created by John Kricfalusi for Nickelodeon.
Oh for scary & gross out jokes..
11 The Loud House
The Loud House is an American animated television series created by Chris Savino for Nickelodeon. The series revolves around the chaotic suburban everyday life of a boy named Lincoln Loud and his ten sisters, to which he survives as the middle child and only son in a large family of eleven children. ...read more.
People may hate it but its one of the few cartoons that is saving Nickelodeon's butt. - egnomac
12 Rocko's Modern Life
Rocko's Modern Life is an American animated television series created by Joe Murray for Nickelodeon. The series centers on the surreal life of an anthropomorphic Australian-immigrant wallaby named Rocko as well as his friends: the gluttonous steer Heffer, the neurotic turtle Filburt, and Rocko's faithful ...read more.
Basically perfected the Ren & Stimpy formula and (for better AND worse) created Spongebob - xandermartin98
13 SpongeBob SquarePants
SpongeBob SquarePants is an American animated television series created by marine biologist and animator the late Stephen Hillenburg for Nickelodeon. SpongeBob is currently the most popular show on Nickelodeon, as well as the longest running show, running for 20 years, and is beginning its 12th season. ...read more.
14 Merrie Melodies
Looney Tunes is already in this list.
15 Scooby-Doo, Where Are You!
Scooby-Doo, Where Are You! is the first incarnation of the long-running Hanna-Barbera Saturday morning cartoon series Scooby-Doo.
16 Adventure Time
Adventure Time is an American animated television series created by Pendleton Ward for Cartoon Network. The series follows the adventures of a boy named Finn (voiced by Jeremy Shada) and his best friend and adoptive brother Jake (voiced by John DiMaggio)—a dog with the magical power to change shape ...read more.
17 Family Guy
Family Guy is an American adult animated sitcom created by Seth MacFarlane for the Fox Broadcasting Company. The series centers on the Griffins, a family consisting of parents Peter (Idiotic Dad) and Lois (Nagging Wife), their children Meg (Socially Awkward Daughter) Chris (Idiotic Son), and Stewie ...read more.
Doug is an American animated sitcom created by Jim Jinkins. The show focuses on the early adolescent life of its title character, Douglas "Doug" Funnie, who experiences common predicaments while attending school in his new hometown of Bluffington. Doug narrates each story in his journal, and the show ...read more.
Rugrats is an American animated television series created by Arlene Klasky, Gábor Csupó and Paul Germain for Nickelodeon.
20 Harvey Beaks
Harvey Beaks is an American animated television series created by C.H. Greenblatt for Nickelodeon. Originally announced to premiere on March 29, 2015, the series instead premiered on March 28, 2015 following the 2015 Kids' Choice Awards.
21 Danny Phantom
Danny Phantom is an American animated series created by Butch Hartman for Nickelodeon. It was produced by Billionfold Studios and distributed in Canada by Nelvana, a Canadian animation company. The series follows a teenage boy who, after an accident with an unpredictable portal between the human world ...read more.
22 Invader Zim
Invader Zim is an American animated television series created by Jhonen Vasquez for Nickelodeon. The series centers on an extraterrestrial named Zim from the planet Irk, and his mission to conquer Earth and enslave the human race along with his malfunctioning robot servant GIR.
23 The Fairly OddParents
The Fairly OddParents is an American animated television series created by Butch Hartman for Nickelodeon.
Yu-Gi-Oh! was aired from 2000 to 2004 in Japan, and 2002 to 2006 in the US. It continues where the Toei Anime Left off. When 10th grader Yugi Muto solves the Millenium Puzzle, Yami Yugi emerges, taking control of him to help his friends. In Duel Monsters, they mostly played children's card games because ...read more.
25 Sonic X
Sonic X is a Japanese anime television series created by TMS Entertainment and based on the Sonic the Hedgehog video game series published by Sega.
26 Kirby: Right Back at Ya!
Kirby: Right Back at Ya!, known in Japan as Hoshi no Kirby, is a Japanese anime series created by Warpstar, Inc.
27 Adventures of Sonic The Hedgehog
Adventures of Sonic the Hedgehog is an American animated series produced by DiC Animation City and Bohbot Entertainment that was based on the Sonic the Hedgehog video game series produced by Sega.
28 Sonic the Hedgehog (SatAM)
29 Teenage Mutant Ninja Turtles
Teenage Mutant Ninja Turtles is an American 3D rendered computer animated television series based on the fictional superhero team. It aired on Nickelodeon in the United States from September 29, 2012 to November 12, 2017.
30 F-Zero: GP Legend
Caillou is a Canadian educational children's television series that was first shown on Télétoon and Teletoon, with its first episode airing on the former channel on September 15, 1997; the show later moved to Treehouse TV, with its final episode being shown on that channel on October 3, 2010. The ...read more.
Ren & Stimpy, South Park and SpongeBob SquarePants are allowed on here.