Dexter is a fictional character and the titular protagonist of the Cartoon Network animated series, Dexter's Laboratory.
Dexter and Lisa would be great friends - Carri796
They even sort of look like eachother - PeeledBanana
2 Alan "The Brain" Powers
3 Anais Watterson
Anais and Lisa would be perfect friends - Carri796
4 Lisa Simpson
Lisa Marie Simpson is a fictional character in the animated television series The Simpsons. She is the middle child and most intelligent of the Simpson family.
It makes sense they both have the same names and are nerds what more can you say?
Both have the same name and are the smartest of their families - PeeledBanana
Bulma is a fictional character in the Dragon Ball manga series created by Akira Toriyama. Bulma is the most significant female character in the series.
6 Mr. Peabody
7 Martin Prince
9 Chloe Park
10 Levi Loud
Yeah they would both defiantly be really good friends, though I really thought that Levi should have been Lex Loud since he kind of look like Dexter from Dexters Lab who he was clearly based off of and he kind of reminds he a little of Lex Luthor who also happens to be a genius.
I hate Levi but he can be a cool genius friend of Lisa. - TLHRules
11 Shikamaru Nara (Naruto)
Shikamaru Nara is a fictional character in the Naruto manga and anime series created by Masashi Kishimoto.
12 Sandy Cheeks
Sandra "Sandy" Cheeks is a fictional character in the Nickelodeon animated television series SpongeBob SquarePants.
13 Jimmy Neutron
James "Jimmy" Isaac Neutron is a fictional character and the main protagonist of the Jimmy Neutron franchise . He is most notably the main protagonist of the 2001 American 3D computer-animated comic science fiction film Jimmy Neutron: Boy Genius and the main protagonist of the American computer animated ...read more.
14 Coco Bandicoot
Coco Bandicoot is a fictional character from the Crash Bandicoot series who first debuted in Crash Bandicoot 2: Cortex Strikes Back in 1997.
15 Twilight Sparkle
Twilight Sparkle is the primary main character of My Little Pony Friendship is Magic. She is a female unicorn pony who transforms into an Alicorn and becomes a princess in Magical Mystery Cure.
No it's Princess Twilight - Carri796
16 Stewie Griffin
Stewart Gilligan "Stewie" Griffin is a main character from the animated television series Family Guy. Obsessed with violence and matricide, Stewie is the youngest child of Peter and Lois Griffin, and the brother of Meg and Chris Griffin.
17 Dr. Fox (Unikitty!)
18 Miles Tails Prower
Miles Prower, more commonly known by his nickname Tails, is a fictional character in Sega's Sonic the Hedgehog series. He is a significant main character after the title character Sonic, who is also his best friend.
19 Uryu Ishida - Bleach
Uryū Ishida is a fictional character and major figure in the anime and manga series Bleach created by Tite Kubo.
20 Phineas Flynn
Phineas Flynn is one of the protagonists of the animated television series Phineas and Ferb. Voiced by Vincent Martella and created and designed by Dan Povenmire, Phineas first appeared along with the rest of the series' main characters in the pilot episode "Rollercoaster." Phineas, along with his stepbrother ...read more.
21 Blossom (Powerpuff Girls)
Blossom is the leader of The Powerpuff Girls and one of the three main protaganists of the show. She was created in 1992 by Craig McCracken. She has long, red hair up in a ponytail with a giant red bow, pink eyes, pink dress with black belt, and white socks with Mary Jane shoes. She is intelligent, ...read more.
Sheldon James Plankton, or simply Plankton, is a character in the Nickelodeon animated television series SpongeBob SquarePants.
23 Ferb Fletcher
Ferbs "Ferb" Fletcher is a British character on the animated television series Phineas and Ferb. The character, voiced by British actor Thomas Sangster, was created by Phineas and Ferb co-founders Dan Povenmire and Jeff "Swampy" Marsh and first appeared in the show's pilot episode, "Rollercoaster."
24 Connie Maheswaran
25 Gretchen Grundler - Disney's Recess
26 The Brain
27 L - Death Note
L Lawliet, exclusively known by the mononym L, is a fictional character in the manga series Death Note, created by Tsugumi Ohba and Takeshi Obata.
28 Dougie (South Park)
29 Sheldon Cooper
Sheldon Lee Cooper, Ph.D., Sc.D., is a fictional character in the CBS television series The Big Bang Theory, portrayed by actor Jim Parsons.
Batman aka Bruce Wayne is a fictional superhero appearing in American comic books published by DC Comics. The character was created by artist Bob Kane and writer Bill Finger, and first appeared in Detective Comics #27. In film, he has been portrayed by Lewis Wilson, Robert Lowery, Adam West, Michael ...read more.
32 Sima Yi
33 Zhuge Liang
34 Sun Tzu
35 Mac - Chicken Run
Belle is a fictional character who appears in Walt Disney Pictures' 30th animated feature film Beauty and the Beast (1991) and in the live action remake Beauty and the Beast (2017). Belle is the intelligent and selfless young daughter of an inventor who does not conform to the normal ways of her small ...read more.
37 Cyborg - Teen Titans
38 Ford Pines - Gravity Falls
39 Dipper Pines - Gravity Falls
Dipper Pines is one of the main characters from the Disney cartoon Gravity Falls which aired from 2012 to 2016.
He is the twin brother of Mabel Pines
40 Daria Morgendorffer
Daria Morgendorffer is a fictional character from MTV's animated series Beavis and Butt-Head and its spin-off Daria.
I'm surprised she's not here - HCShannon
41 Applejack (My Little Pony)
Applejack is a female Earth pony and one of the main characters of My Little Pony Friendship is Magic. She lives and works at Sweet Apple Acres with her grandmother Granny Smith, her older brother Big McIntosh, her younger sister Apple Bloom, and her dog Winona. She represents the element of honesty. ...read more.
42 Dr. Buttocks - Pac-Man and the Ghostly Adventures
PacMan and the Ghostly adventures!
43 Himari Arisugawa / Cure Custard
44 Chester McTech (Beverly Hills Teens)
45 Velma Dinkley - Scooby Doo
Velma Dinkley is a fictional character in the Scooby-Doo franchise. She is usually seen wearing a baggy orange turtleneck, short red pleated skirt, knee socks, Mary Janes, and most prominently, a pair of square glasses, which she frequently loses.
46 Rick - Rick and Morty
47 Ghoulia Yelps - Monster High
48 Techrat - Jem & The Holograms
49 Ruru Amour/Cure Amour
SHE'S A LITERAL ROBOT!