Top Ten Worst Diseases


They kill and torture...but what the worst? Don't agree with the list? Vote for an existing item you think should be ranked higher or if you are a logged in, add a new item for others to vote on or create your own version of this list.

The Top Ten

Cancer is a horrible disease! Some people in my entire family had cancer. I hope one day there is a cure for cancer. I wish cancer wouldn't kill so many people. I am so glad I haven't had cancer and I am only 15 years old.
It attacks you from the inside out, terrible way to go... It destroys your bodies cells.
I lost somebody to cancer. His name was David Bailey. Iam still missing him. Whenever I see his house I just cry. I used to blame his death on myself. Because before he died I was naughty. At least he is in a better place where angels and peace and doves and god and Jesus are
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Have you see the videos of people with rabies trying to drink water and can't because of hydrophobia, pretty sad stuff. Worst part is that their basically doomed.
Rabies is scary. I've seen this episode of monsters inside me and this girl was having strange mood changes, trouble focusing eyes and collapsing into seizures and shaking and then she died.
Swine flu isn't dangerous and you can escape cancer but with rabies you are dieing a slow death.
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3Ebola Haemorrhagic Fever
Severe internal bleeding and at least a week of your organs being reduced to mush. Then after all the pain and suffering you die of hypovolemic shock from blood loss.
I must be really brave - I've read the Hot Zone while eating despite all the blood and gore of it. Ebola seems not only to be extremely lethal, it also seems to be quite fascinating. But of course, I always find the more deadlier germs/diseases more interesting than the milder ones.
Don't forget Ebola's sibling, Marburg - It's not as deadly as Ebola, but it still has a very high mortality rate and the same sort of symptoms. Nice or what?
If you don't fear death, go and walk into a biosafety level 4 facility. I guarantee you won't find AIDS or Cancer there. What you will find is the most frightening, terrifying disease known to man. You can pick a strain, but your chance of survival will always be the lowest possible.
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4Fatal Familial Insomnia
no cure for this disease prevents you from sleeps slowly eats away at the thalamous and eventually kills you its the worst prion disease if one member of your family has it you have a 50/50 chance of getting it


my grandmothers side carries this horrible gene. I've heard about my previous ancestors dying with it & witnessed my grandmother & uncle die with it. I pray that I am not a carrier of this gene.
With this, it seems there is no escape, even temporarily, from the reality of your imminent end. One can usually sleep and momentarily forget the disease which ails you, but with this, you're awake for the whole thing, at least to a degree.
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They have found a cure to it but you can only get it in North America.



freddie mercury died of aids its the worst thing going


You can survive Cancer but you can't escape AIDS.


can be spread through sexual contact, whereas cancer cannot.
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Even though there are tablets against this, many people who cannot afford these drugs easily die of malaria. It is worse then any other disease because the parasite injects the disease in without you knowing so you could get it and still not know.


9Yellow Fever
Damages your adrenal glands and your nervous system causing unirrational fears such as water and lots of people have been found dead after a yellow fever epidemic
It's irrational fears and it is bad untreated it can kill thousands of people

It is a hopeless disease. There is no cure, no treatment, very little help or understanding. It strips the person you love of every dignity and ounce of themselves, reducing them to a vegetable. Not only that the people left behind watch this helpless. In any other disease medicines or food might be withdrawn if there was no symptom control. In this case you watch as they become childlike. Husbands and children become carers, carers with no hope or relief. Just when you think it can't get worse it does. My mum has had Alzheimer approx 6 years she is 61 she will die old, 70-80 but really she die died years ago. Now we just watch and care as best we can as the depression, agitation, hallucination and language reduce as well as incontinence and other physical symptoms.
This person looks old, not like the picture I see in my head when I think mum. This person looks at me like she has never seen me unlike the mum I remember. There is so much more to say but I do not have the words to express
My grandpa has Alzheimers... I can't even explain how horrible it is. It takes such a toll on you and your family. I can barely remember who my grandpa really is. Most people die physically before they die mentally. But with Alzheimers, the patient dies on the inside years before they are technically 'dead'. Pray that no one in your life EVER get Alzheimers. It changes everything forever. And there is nothing that can help it.
I have very bad experience, because my best friend, my everything, my whole world, got this disease. It was my mother, the worst disease is Alzheimer's at that moment I wish my mother had cancer not Alzheimer, when I see commercial about or in newspaper it hurts me very much.
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The Contenders


I've had the real Diabetes (type 1) for over ten years now. Since I was seventeen I've been injecting myself on average 5 - 6 times a day and pricking my fingers and forcing blood out of the end so to test the sugar content of my blood. If I tally the total number of injections then I would estimate it to be almost 19, 000. Now remember that in those ten years I have not had a day off. Every day, more injections, into already bruised parts of my body. The bruising never goes, the humiliation of your own body turning against you and coming very close to killing you is too much. I've woken from the warped nightmares of hypoglycemic comas more times than I can remember and every new day is a test to prevent the next episode from being the last. There is no end to this disease, it will get you eventually.
My dad has diabetes and he makes me sad he has the highest type if you have diabetes don't drink diet cause that will kill you
I have diabetes (type 1) and to me its not that bad. Sometimes I cry because of it. Eventually I started to get sick of taking shots, but then I remind myself that if I don't I will die.


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I watched my mother deteriate over 17 years before this destructive cruel disease killed her off. Now I am watching the same thing happen to my younger sister and its heartbreaking. She can only lie down day and night and is now starting to choke even on the milk shakes she can only feed on. She will soon have a tube through her stomach to feed her. This disease affects the nervous system and shrinks the brain. No one can be cured from this. It is a slow and awful way to die
River dance, that's funny but it is more like standing on 2 different waterbeds at the same time. Definitively in the top 5. The 3 top reasons for dieing from it are accidents, suicide and choking because you can't swallow
It is not very nice
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This disease is the highest death toll in history, over 500 million died of it, the bubonic plague only killed about 200 million.
Very sad and scary.
I have that it just sucks.

My grandfather died of this disease. There is a sort of cure. If you fight and they get the dosage wright then you live longer. It a genetic thing and is actually passed through the mother but normally a man gets it. Early signs are hands shaking when you sit down and aren't doing things with your hands. I watched a man who could put me on his shoulders and laugh all day die on a hospital bed in a coma like state. He wasn't even alive long enough for the doctors to figure it out. It's bad, really bad.
The victims of the disease are not at fault for their condition and there is no cure, only symptom management, as far as I know. I don't know why rabies is ranked higher/worse than this. But then again there is a lot I don't know.
The legendary boxer Muhammad ali has this disease when he went to joe fraziers funeral that's when people started to know this even though he had since 1984
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ALS is the worst of all diseases- it robs you of your body and dignity but leaves you with your mind. You are unable to communicate, use your limbs eat, swallow your own saliva or even hold up your head yet you know exactly what is going on around you. There is no cure and no fast death. I can not imagine a worse disease to get.
This is a horrid condition. A few friends had/have it. There are 4 types of Motor Neuron diseases out there 2 of which are fatal, one of which is not and one which is not fatal unless it mutates into one of the fatal two. ALS is one of the two fatal ones and unfortunately the most common motor neuron disease. In a few cases, ALS is not fatal and in a few other cases, people with ALS live longer than the usual 2 to 5 years (Stephen Hawkings being a famous example). But in most cases, it is a cruel and horrid death.
ALS/MND is the cruelest disease out there...especially when there is not a lot of research funding to find the cause and or cure!
Patients usually contract Pneumonia or some other sort of respiratory illness in the last stage of this disease in which they already can't eat or swallow because they have lost their neck muscles, (so they starve), they can't breath or cough up phlem because they have no diafram muscles and lungs are too weak to breath, (so they constantly breath with a crackle from phlem in their chest) Pain is experienced at the end in which morphine is the only comfort...Death is so horrific at the end!...I wouldn't wish this disease on my worst enemy!
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The most difficult disease can be infected by and is in the degree of cancer, can not work, you hate everything, wish for death, to live by, the pain and dizziness all the time, not Thhtml light, you hate your life, fatigue and failure and nausea with the morning, become your life suffering real, it's in the same degree of risk of cancer in terms of Aaltather on yield, but it is not deadly like him


19Bubonic Plague
It has one of the highest total population kill ratings of all time
This is a terrible disease


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20Swine Flu
80 deaths and 100 cases as of today


Very dangerous, see SARS, and this disease caused many deaths.


another disease like SARS


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21Multiple Sclerosis
I have ms and I wish people /family could see what my husband and daughters see. For they see the pain the frustration when you can't hold a pen or fork, when your walking along then your in a heap leg less your speech is slurred, tingling in your feet, hands and legs, bladder problems, sight. Yet people /friends and family say there's nothing wrong with you. You look so well. Yet I know there is lots more to look forward to. It's my husband and daughters I feel for, as you can see the sadness and pain in their eyes
A dreadful disease, my sister died two weeks ago after suffering for 30 years.
It affected all parts of her body, becoming totally reliant on carers feeding her and all aspects of personal care.She was robbed of all dignity.She found it hard to communicate as her speech was affected, and also sight was affected.She was in lots of pain too.I miss my sister.I loved her
This can be big emotional, physical, financial setback for the patient and family of the patient.
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22Manic Depression
I my self suffering with it...
Feeling helpless...

This is the worst trust me, my wife is a NP, she told me that if this gets out, we are done
If you get this sickness you die straight away

It is the worst thing you can imagine. I would love to have cancer instead and die on that. What makes a depression so terrible? You don't have any positive feelings anymore and you think you will never have them again. All I can think of is death and tragedy for the ones I will lose. There can't be a god if there's such a thing as depression.
I suffer from depression. Let me just say that it destroys your happiness and will to live, and it eventually makes living unbearable. I'd rather have a disease that is curable, thank you very much.
You may as well be dead, watching everyone around you be happy and you can't join in. Having anhedonia is like being the walking dead.
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Not really a deseise, but still awfull. Schizophreia suffers more often than not have suasidle tendences.

I was 10 when it started When I was 12 I was diagnosed. I am 14 and still not done with the meds or doctor visits.

It is so sad people end up literally looking like elephants no laugh it is scary my brother has it it is terrible

28Crohn's Disease
My boyfriend suffers from Crohn's disease and he has done since he was 12 years old. He is now 25. This disease has spread from his mouth where his lips swell and he has ulcers and blisters that kept on reoccurring then it moved down to his chest and lungs where more ulcers appeared and he was unable to breath properly without being in pain. After it traveled down into his stomach and gave him multiple stomach ulcers which was unbearably painful when eating therefore the malnutrition began and hr drastically lost weight. To treat the Crohn's and this time he was on steroids which allowed him to gain weight but too much and for a young boy in secondary school was really difficult.

He eventually came off the steroids and got back to a healthy weight when the Crohn's then moved location to his anus causing terribly uncomfortable abscesses which were continuously coming back after being drained. The doctors where at a loss as to what to do as he began to loose all appetite, developing chronic fatigue and was having to have his bowels open up to 25 times a day. His weight plummeted to a dangerously unhealthy weight for his height and he became dehydrated. This meant the Crohn's was so severe down there the next medical decision was to have surgery and input a colostomy bag. He was only 21.
This was a life saving decision and continued to improve his life and his weight came back up and he was getting back on track. The Crohn's hadn't gone away as it is incurable so now it was in his large intestine. The treatment for this was an infliximar infusion once every 6 weeks. This helped very much until the third week when he would begin to feel all the symptoms again, loss of appetite, fatigue and multiple loose stool and bowel movements.

Finally the final option is to now remove the entire large intestine and rely only on the small intestine. Other than this there are no further treatments he can try. Only to work out the perfect balance. Crohn's is one of the worst diseases when escalated to this level.
I'd rather had all my bones broken in my body than having depression
I got a lot of stuff on this list b this one hurts me the most


Those kids are so not lucky too have that cauze when you can't walk for a long time and those kids is like 5 years and they can't walk for the rest of ther lif, they can but they can only walk with some help and that's why I took this one :o

Epilepsy is bad the reason why it is bad because you don't know when your going to have one which is a seizure that is what epilepsy really is I have them I had a seizure one time I was talking to my step dad and after I got threw talking to him I laid down and he came down to my house I went to sleep after I got threw talking to him I woke up and I on the couch I had dirt all over me and I had a black eye from were I had fell outside and what made it so bad I did not even know that I had even went outside but I did and I didn't realize it but my step-dad woke me up on the couch and said what happened to you and I said what are you talking about and he said well you have a black eye talking about me I said what I don't have a black eye.but I did and I I also had a couple of wrecks in a car from seizures.because I wasnt taking my medicine like I was post to be so that's why I was having my seizures but when I take my medicine I'm alright but I hope I don't have none taking my medicine I have never had one while on medicine.i had a friend that had seizures to and I watched him when he had one and it was not good he fell straight back and he did not catch hisself he just fell straight back and he also bit his tongue to and blood was running down the side of his face and he started shaking
Still largely misunderstood and stigmatized by society and as a sufferer I can vouch for the fact that it is horrifying. It's much more than just the typically portrayed uncontrolled muscle motions and involves sensory torsion, intellect wrenching, perception skewing, psychosis, and additional experiences that, to put simply, go beyond any explanation. And add to that, mind-blowing pain that ones tortured mind has to interpret, and the element of chance wherein these effects can take over your existence at any moment, and can be immediately fatal.
Effects can include Alzheimer's-like symptoms, and early onset of Alzheimer's, diabetes from medications, Parkinson's-like effects, MS-like effects, it can cause schizophrenia and manic depression, similar to ALS, has effects similar to Locked In Syndrome (though this is the first I've heard about LIS, which must be horror as well),... And frankly, any disease like Noma causing disfigurement (or like Treacher Collins) is largely a disease of others' perception of a normal person suffering from disfigurement, and considering disfigurement "bad" is just a sickness of the observer's mind. Tetanus sounds like it has similarities to epilepsy, but without the immediacy of epilepsy, and without the alterations of mental function.
Common cold? Give me a f*****g break.
This list is a joke.

31Common Cold
Bloody fantastic. Makes me want to whip out my tichy Thomas and choke my chicken.

32Motor Neurone Disease
I think motor neurone disease should be at the top because it is a wicked disease that ravages your body in a matter of months it is incurable and usually fatal. It takes away your body movements and even your eating and speech are affected as well.
Can't understand why this illness has not previously been listed.A dreadful disease with no cure..leads to death.
The mind remains intact whilst the body slowly fails to function

33Harlequin's Disease
A horrible yet extremely rare skin disease that occurs within the womb. The skin of the baby is not able to keep moisture and thus it hardens an cracks in diamond shaped scales, much like Victorian harlequin clown outfit.

34Sickle Cell Anemia

Fever, and the bumps are pretty itchy, once you scratch blood and chemicals start coming out
Killed one third of the people that got it.
Pocahontas might have had small pox, maybe

36Necrotizing Fasciitis
This disease is nasty as hell no joke my friend saw images on this disease and he threw up


38Spanish Flu
Some scientist injected some healthy lab mice with Spanish flu and they died in three days!
100 million people died from Spanish flu in a week!


39Tourette's Syndrome
Just how bad is it to live with uncontrollable reactions to certain things. To the point where people don't understand you, you get bullied and harassed, rejected from society with no real way of getting back in. The saddest part about Tourette's syndrome is that it doesn't have to be so bad. People could be more understanding of such matters, but society has perverted it like most everything else to where one who has it has no chances of living a normal life.
I have got it. People always make fun of you. Once this boy and a mob were chasing after me shouting; Tourette's freak, chips (which I say when I tic), creep I ran inside I was sobbing. Please don't freak out. At this I used an sometimes bite my hand. Because I fell cross at myself and my dad called me evil hearted and he used to slap me round the head when I ticked I am getting better now and getting help

40Locked In Syndrome
This is an intense disease. You get it from being locked in places, do not laugh until you have contracted this disease. I can not even lock my car door with me in it without the f out.

41Dengue Hemorrhagic Fever
You get this virus by mosquito bites, similar like malaria

42Lupus Nephritis
My aunt died from lupus when I was five or four and she had three wonderful sons

Anthrax is a deadly desiese where you have to fight to survive. The only medicine is the vaccine, which some people are allergic to it.

An extreme case where your skin looks horrible and people look at you as if you are some alien... It oozes out your confidence and you are never free from the itching tendency.. Wonder why it is not in the top ten...
It runs in my family. but we didn't know what it was (even though we all had it) until my brother was born. (he is five now) the doctor told my parents he had eczema and they got scared because they didn't know if it was serious
Eczema is horrible, but can be controlled and is not fatal.

45Stevens-Johnson Syndrome
Horrible my coison had this disease the doctors said he's going to die but 10 percentage he could survive but he did survive. Its all your skin peeled of and bubbles form up (caused by your white blood cells) I'm eight years old and I happy I not to have this disease

46West Nile Virus




50Congenital Heart Disease

A condition which is caused by a secondary infection like meningitis that causes csf fluid to become trapped and unable to circulate normally causing your brain ventricles to enlarge squeezing your brain in your skull causing headaches, nausea, vomiting, and gait problems.

Makes breathing more difficult than it should be.

53Creutzfeldt–Jakob disease
CJD is a degenerative neurological disorder (brain disease) that is incurable and invariably fatal.


55Arnold-Chiari Malformation

56Cancrum Oris (a.k.a Noma)

57Avian Flu

I know it couldn't'kill, but I've got it once, and believe me, once you experience it, you will wash your hand before eating your whole life

59Cerebral Palsy

60Fatty Liver Disease

61Cirrhosis of the Liver
You have to put a scientific straw into your liver in order for the cure.


A slow and very painful way to die. your body stays all swollen up, you vomit all the time, you have insane itching that keeps you awake 24 hours a day, and everyone, including drs. think you must have been an alcoholic or drug addict. not always true!

This disease kills infants in there sleep. So don't put a baby to sleep on its stomach. It's so sad when a baby dies from SIDS ( sudden infant death syndrome. )

The person with TMAU smells like rotten fish. And, he has to bear embarrassment, humiliation from people around him/her. This condition is due to Inability to body to break foods.

The other 100% mortality rate


66Polycystic Kidneys

67Obsessive Compulsive Disorder
A horrible, disabling and very misunderstood illness.

Tooo horrible so true

69Chicken Pox (Varicella)
Horrible big ugly spots

It doesn't hurt you unless it goes untreated... then it can give you heart and lung issues, but even when it's being treated/ monitored, it can be scary knowing your spine is shaped like a snake... O_O I was recently diagnosed with it, and it's so bad for me I might need surgery... :( The curve in my spine is 65 degrees, but I've seen people with it so bad their backs arch to the side badly, and their ribs stick out so far they look like skeletons... It's pretty scary! (Heh heh.. I'm a scaredy cat so it's twice as scary for me... )


72Scarlet Fever

Because of the meds it would make the person have a low immune system and they could get sick very easily from any other diease in here and die from that diease

Disabling physically- enough said. Sheer torture.

Can be very painful and lifelong troubling

Why does no one warn you that this is a debitating life sucking illness that can be impossible to recover from- it can begin with just being nervous around something/someone and end with the most terrifying depression in which you have no positive feelings whatsoever, nothing to feel anymore for family and friends - look it up- the worst attacks can make you believe you're dying and get you locked in mental hospital- and another warning:-antidepressants can make you get like this - they can worsen any depression to the point you want to due and gave nothing g to live for. You can lose EVERYTHING- family friends job house.. , enjoyment if life, confidence, independence, confidence to drive it go anywhere in your own ever again; you can end up hiding from the people you live because you can't feel love - or anything except sadness and terror- ever again. For gods sake why isn't there education about ANXIETY- so easy to prevent it if we knew it was possible that something as simple as nervousness. Can lead to terror regarding loss and complete debilitating ; resorting to staying in bed all day unable to do anything if feel anything fit anyone.

Mono is terrible at least it can't kill you

78Ehlers-Danlos Syndrome
This reduces your quality of life, leaving you reliant on pain medications and, possibly, a wheelchair. Heart problems and gastrointestinal problems follow suit. You are living a life where you are in constant pain. And it can cause spontaneous organ rupture, depending on the type

I also have autism and posslibly ADHD and ODD But autism did make my life alittle more interetsting. I just hate it when everyone thinks I'm stupid just because I have a disorder
My hero, Temple Grandin has autism. She is very intelligent and has proved people who said autistic people were dumb wrong. She is so amazing. Keep up the good work, temple!


I only have ADHD and OCD and small amounts of Turetts. People only tease me because my OCD acts up and I get really nervous around popular people (i tend to get bullied) forcing me to get awkward. it sucks.


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80Asperger Syndrome

If this was true I would be dead right
I have ADD and ADHD and because of that everyone things I'm miss bouce of the walls or talk a holic but I can't help it ;-[


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This list was created 6 years, 224 days ago and has been voted on over 1,000 times. This top ten list has been remixed 2 times.

Updated Monday, September 15, 2014

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