1 Lain Iwakura - Serial Experiments Lain
2 Shiro - Deadman Wonderland
3 Johan Liebert - Monster
Definitely one of the most unique characters I've ever seen. - Kiteretsunu
4 Saber - Fate Stay Night
Saber is a fictional character from the Japanese visual novel and anime series Fate/stay night by Type-Moon and its prequel, Fate/Zero, by Type-Moon and nitroplus. She is the the Saber-class Servant of Kiritsugu Emiya during the Fourth Holy Grail War in Fate/Zero and the Saber-class Servant of Shirou ...read more.
5 Hakudoshi - Inuyasha
6 Rin Okumura - Blue Exorcist
Rin Okumura is a fictional character in the manga and anime series Blue Exorcist created by Kazue Kato. He's known for being the son of satan and trying to kill him. He is the main Protagonist in Blue Exorcist. His notable feature is the blue sword in which he draws when in trouble
7 Edward Elric - Fullmetal Alchemist
Edward Elric, commonly nicknamed Ed, is a fictional character and the protagonist of the Fullmetal Alchemist manga series and its adaptations created by Hiromu Arakawa.
I liked Edward's Personality. And it was realistic and unique - Kiteretsunu
8 L Lawliet - Death Note
L Lawliet, exclusively known by the mononym L, is a fictional character in the manga series Death Note, created by Tsugumi Ohba and Takeshi Obata .
9 Levi Ackerman - Attack on Titan
Levi Ackerman is a fictional character in the manga and anime series Attack on Titan, also known as Shingeki no Kyojin in Japanese, created by Hajime Isayama. He accompanies the main protagonists in the second half of season 1. His most notable feature is being "Humanity's strongest".
10 Zetsu - Naruto Shippuden
Zetsu is a fictional character in the anime and manga franchise Naruto, created by Masashi Kishimoto.
Black on one side, white on the other, each side with a separate personality, can divide into separate beings; part man, part plant, with Venus fly-traps at the sides of his head. He travels thru root systems underground. Pretty unique.
11 C.C. - Code Geass
C.C. is the pseudonym of a fictional character in the Code Geass: Lelouch of the Rebellion anime series by Sunrise. C.C.'s real name is never shared with the audience, despite eventually being learned by protagonist Lelouch Lamperouge.
12 Haibara Ai - Detective Conan
For me the most unique character I've seen in anime. - Kiteretsunu
13 Grell - Black Butler
14 Yoshikage Kira